Autoantibody adsorbent and apparatus for removing autoantibodies

Chemistry: natural resins or derivatives; peptides or proteins; – Proteins – i.e. – more than 100 amino acid residues – Separation or purification

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2105021, 210679, 436824, 530416, 604 5, 604 6, A61N 500, B01D 3900, C07K 318

Patent

active

052585034

ABSTRACT:
An adsorbent for an autoantibody or immune complex produced by combining an autoantibody with its homologous antigen, which comprises a water-insoluble porous material and a compound having an anionic functional group immobilized onto said material, an apparatus for removing an autoantibody or immune complex thereof using the above-mentioned adsorbent and a method for removing an autoantibody or immune complex thereof from body fluid by passing body fluid through the above-mentioned removing apparatus. According to the present invention, the autoantibody or immune complex thereof can be selectively removed from body fluid without removing useful components in body fluid.

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Herbert, et al. (Eds.), Dictionary of Immunology, Third Edition, Blackwell Scientific Publications, Oxford, 1985, p. 85.
Affinity Chromatography Principles and Methods, Publication of Pharmacia Fine Chemicals, 1974.

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