Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Heterocyclic carbon compounds containing a hetero ring...
Reexamination Certificate
2011-07-19
2011-07-19
Wilson, James O (Department: 1624)
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Heterocyclic carbon compounds containing a hetero ring...
C514S311000, C544S237000, C546S152000
Reexamination Certificate
active
07981891
ABSTRACT:
The present invention relates to chemical compounds having a general formula Iwherein A1-8, D′, L1, L2, R1, R6-8and n are defined herein, and synthetic intermediates, which are capable of modulating various protein kinase receptor enzymes and, thereby, influencing various disease states and conditions related to the activities of such kinases. For example, the compounds are capable of modulating Aurora kinase thereby influencing the process of cell cycle and cell proliferation to treat cancer and cancer-related diseases. The invention also includes pharmaceutical compositions, including the compounds, and methods of treating disease states related to the activity of Aurora kinase.
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Deak Holly
Geuns-Meyer Stephanie
Hodous Brian L.
Hua Zihao
Martin Mathew
Amgen Inc.
McDowell Brian
Prabhakar Reddy G.
Wilson James O
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