Augmenting factors for human antibody production and process for

Details Augmenting factors for human antibody production and process for Augmenting factors for human antibody production and process for

1984-01-25

1986-06-10

Wiseman, Thomas G.

Drug, bio-affecting and body treating compositions

Fermentate of unknown chemical structure

Having a known elemental analysis

435 68, 435241, 514 2, 514 8, 530351, 530387, A61K 3518, C07K 1506, C12N 502, C12P 2100

Patent

active

045942455

ABSTRACT:
Augmenting factors for human antibody production having a molecular weight of 2,000-4,000 are prepared from the supernatant of cultured human lymphocytes. Nylon wool-adherent cells of human lymphocytes are separated from nylon wool-passed cells, and are then cultured, dialyzed and lyophilized. The factors espeically augment and enhance the production of immunoglobulins, IgG and IgM.

REFERENCES:
patent: 4001080 (1977-01-01), Goust et al.
patent: 4132776 (1979-01-01), Jeter
patent: 4390623 (1983-06-01), Frabricius et al.
Cohen et al, Inhibition of Migration of Tumor Cells in Vitro by Lymphokine-Containing Supernatants, J. of Immunology (1978) 121: 840-843.
Neville et al, Activation of Fc Receptor-Bearing Lymphocytes, by Immune Complexes, J. Immunol., 128: 1063-1068 (1982).

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