Augmentation and repair of vocal cord tissue defects

Details Augmentation and repair of vocal cord tissue defects Augmentation and repair of vocal cord tissue defects

2000-08-08

2008-08-19

Matthews, William H. (Department: 3774)

Surgery

Miscellaneous

Methods

C424S093700

Reexamination Certificate

active

07412978

ABSTRACT:
A method for corrective surgery in a human subject of a vocal cord defect amenable to rectification by the augmentation of tissue subadjacent to the vocal cord defect, the method comprising: placing an effective amount of autologousin vitrocultured cells into a vocal cord tissue of the subject in a position subadjacent to the vocal cord defect, wherein the vocal cord tissue is selected from the group consisting of a scar, Reinke's space, a muscle of the vocal cord, and the lamina propria, wherein thein vitrocultured cells are obtained by culturing a plurality of viable cells retrieved from the subject, and wherein the cultured cells are suspended in a collagen or modified collagen solution prior to injection of the cultured cells. Thein vitrocultured cells can be fibroblasts, e.g., fibroblasts derived from dermis, fascia, connective tissue, or lamina propria.

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