Organic compounds -- part of the class 532-570 series – Organic compounds – Carbohydrates or derivatives
Reexamination Certificate
2002-05-23
2008-08-12
Harris, Alana M. (Department: 1643)
Organic compounds -- part of the class 532-570 series
Organic compounds
Carbohydrates or derivatives
C536S018700, C536S022100, C536S023100, C530S300000, C530S350000, C435S069100
Reexamination Certificate
active
07411055
ABSTRACT:
The present disclosure provides attractin/mahogany-like polypeptides and fragments thereof, polynucleotides encoding such polypeptides and fragments, processes for production of recombinant forms of such polypeptides, antibodies generated against these polypeptides or fragments, and assays and methods employing these polypeptides, antibodies, and polynucleotides.
REFERENCES:
patent: 6274339 (2001-08-01), Moore et al.
patent: 6933132 (2005-08-01), Duke-Cohan et al.
patent: WO 00/05373 (2000-02-01), None
patent: WO 00/15651 (2000-03-01), None
patent: WO 01/16156 (2001-03-01), None
Lazar et al. Transforming Growth Factor alpha: Mutation of Aspartic Acid 47 and Leucine 48 Results in Different Biological Activities. Molecular and Cellular Biology 8(3): 1247-1252, Mar. 1988.
GenCore database alignment between Applicants' SEQ ID No. 1 and nucleic acid seqeunce of Nagase et al., 3 sheets, 1998.
GenCore database alignment between Applicants' SEQ ID No. 1 and SEQ ID No. 18, 3 sheets, 2002.
GenCore nucleic acid databases. Alignment between Applicant's SEQ ID No. 1 and sequence of WO 200015651 A1 (published Mar. 23, 2000), 3 pages.
Duke-Cohan JS, et al., “Attractin (DPPT-L), a member of the CUB family of cell adhesion and guidance proteins, is secreted by activated human T lymphocytes and modulates immune cell interactions,”Proc. Natl.Acad. Sci. USA, 95:11336-11341, Sep. 1998.
Gunn TM, et al., “The mousemahoganylocus encodes a transmembrane form of human attractin,”Nature398:152-156, Mar. 1999.
He L., et al., “A biochemical function for attractin in agouti-induced pigmentation and obesity,”Nature Genetics27:40-47, Jan. 2001.
Kuramoto T, et al., Attractin/Mahogany/Zitter plays a critical role in myelination of the central nervous system,PNAS98(2):559-564, Jan. 16, 2001.
Malik R, et al., “Expression of Attractin and Its Differential Enzyme Activity in Glioma Cells,”Biochem. and Biophysical Research Communications284:289-294, 2001.
Nagle DL, et al., “Themahoganyprotein is a receptor involved in suppression of obesity,”Nature398:148-152, Mar. 11, 1999.
Tang W, et al., “Secreted and membrane attractin result from alternative splicing of the human ATRN gene,”PNAS97(11):6025-6030, May 23, 2000.
Nagase et al., “Prediction of the Coding Sequences of Unidentified Human Genes. IX. The Complete Sequences of 100 New cDNA Clones from Brain Which Can Code for Large Proteinsin vitro” DNA Res5:31-39, 1998.
EBI Database EMBL Accession No. 060283, Aug. 1, 1998.
EBI Database EMBL Accession No. AB011106, Apr. 10, 1998.
Bellas Christine M.
Harris Alana M.
Immunex Corporation
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