Attenuation of cytomegalovirus virulence

Drug – bio-affecting and body treating compositions – Antigen – epitope – or other immunospecific immunoeffector – Virus or component thereof

Reexamination Certificate

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C424S205100, C424S230100, C435S005000

Reexamination Certificate

active

07611718

ABSTRACT:
A method is provided for attenuating a cytomegalovirus comprising functionally disrupting an open reading frame of a Toledo genome region or its homolog and making chimeric CMV virus genomes.

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