Attenuating mutations in Venezuelan Equine Encephalitis virus

Details Attenuating mutations in Venezuelan Equine Encephalitis virus Attenuating mutations in Venezuelan Equine Encephalitis virus

1994-05-27

1996-04-09

Mosher, Mary E.

Drug, bio-affecting and body treating compositions

Antigen, epitope, or other immunospecific immunoeffector

Virus or component thereof

4352351, 435236, 536 2372, 4241991, A61K 39193, C12N 700, C12N 704, C12N 1540

Patent

active

055059473

ABSTRACT:
Novel attenuating mutations of Venezuelan Equine Encephalitis (VEE) are disclosed. Further aspects of the invention include an infectious VEE virus transcript encoded by cDNA clones, infectious VEE virus particles, and pharmaceutical formulations containing such infectious particles. Also disclosed are recombinant VEE virus containing a heterologous RNA segment.

REFERENCES:
patent: 5185440 (1993-02-01), Davis et al.
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Kinney, R. M. et al. 1989. Virol. vol. 170 pp. 19-30.
Davis, N. L., A Molecular Genetic Approach to the Study of Venezuelan Equine Encephalitis Virus Pathogenesis, Arch Virol 9:99 (1994).
Davis, N. L., Attenuating Mutations in the E2 Glycoprotein Gene of Venezuelan Equine Encephalitis Virus: Construction of Single and Multiple Mutants in a Full-Length cDNA Clone, Virology 183:20 (1991).
Frolov, I. V., et al., Recombinant VEE Virus Expresses HBsAg, Proceedings, IXth International Congress of Virology, p. 67. (Aug. 8-13, 1993).
Hahn, C. S., et al, Infectious Sindbis Virus Transient Expression Vectors for Studying Antigen Processing and Presentation, Proc. Natl. Acad. Sci., 89:2679 (1992).

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