Drug – bio-affecting and body treating compositions – Antigen – epitope – or other immunospecific immunoeffector – Bacterium or component thereof or substance produced by said...
Patent
1997-08-21
2000-10-24
Swartz, Rodney P.
Drug, bio-affecting and body treating compositions
Antigen, epitope, or other immunospecific immunoeffector
Bacterium or component thereof or substance produced by said...
4242001, 424 932, 435243, 4352531, 435441, 435471, 530300, 530350, 530820, 530825, 536 231, 536 237, A61K 3904, C12N 100, C07K 100, C07H 2102
Patent
active
061363243
ABSTRACT:
Attenuated strains of Mycobacterium, particularly species of the tuberculosis complex, have the mycobacterial cell entry (mce) gene functionally disabled. The gene may be disabled by an insertion into the gene which disrupts the mycobacterial cell entry function thereof of a selectable marker which is used for screen for homologous recombinants in which a double cross-over event has been effected. The attenuated strains may be used in the immunization of hosts against Mycobacterium disease.
REFERENCES:
patent: 4681762 (1987-07-01), Oeschger et al.
patent: 5663317 (1997-09-01), Falkow et al.
patent: 5700683 (1997-12-01), Stover et al.
Parker et al., "Comparison of PCR-generated fragments of the mce gene from Mycobacterium tuberculosis, M. avium, M. intracellulare, and M. scrofulaceum" Clin.Diag. Lab. Immunol., vol. 2, No. 6, pp. 770-775, Nov. 1, 1995.
Grange, J.M.; Gibson J; Osborn, T.W.; Collins, C.H. and Yates, M.D. (1983), Tubercle 64: 129-139.
Shepard, C.C. (1958), J. Exp. Med. 107: 237-45.
Arruda, S., Bonfim, G.; Huma-Byron, T. and Riley L.W. (1993), Science 261: 1454-1457.
Azad, A.K., Sirakova T.D., Rogers L.M., Kolttukudy P.E. (1996) PNAS 93: 4787-4792.
Balasubramanicm V.M. et al (1996) J. Bacteriol 178:273-279.
Beyrat J.M., Berthet F.X., Gicquel B. (1995) PNAS 92:8768-8772.
Reyrat JM, Lopez-Ramirez G, Ofredo C, Gicquel B, Winter N. (1996), Urease activity does not contribute dramatically to persistence of Mycobacterium bovis bacillus Calmette-Guerin. Infect. Immun. 64. pp. 3934-3936.
Jacobs Jr WR., Kalpana GV., Cirillo JD., Pascopella L, Snapper SB., Udani RA., Jones W., Barletta RG., Bloom BR. (1991) Genetic systems for Mycobacteria. Methods Enzymol. 204 pp. 537-555.
Anderberg, R.J., Strachan, J.A. and Cangelosis, G.A. (1995) Bio Techniques 18:217-219.
Flesselles Bruno
Klein Michel H.
Connaught Laboratories Limited
Swartz Rodney P.
LandOfFree
Attenuated strains of mycobacteria does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with Attenuated strains of mycobacteria, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Attenuated strains of mycobacteria will most certainly appreciate the feedback.
Profile ID: LFUS-PAI-O-1960667