Drug – bio-affecting and body treating compositions – Antigen – epitope – or other immunospecific immunoeffector – Virus or component thereof
Patent
1997-11-24
1999-12-14
Mosher, Mary E.
Drug, bio-affecting and body treating compositions
Antigen, epitope, or other immunospecific immunoeffector
Virus or component thereof
4242091, 4242181, 424815, 4242021, 4242011, 4352351, 435236, 435237, 435239, A61K 3912, A61K 39145, C12N 704, C12N 708
Patent
active
060013702
DESCRIPTION:
BRIEF SUMMARY
FIELD OF THE INVENTION
This invention relates to a new attenuated strain of the virus causing the swine disease known as porcine reproductive and respiratory syndrome (PRRS). The attenuation and replication procedure of the virulent strain by using a new cell clone obtained from monkey kidney allows the preparation of vaccines and diagnostic kits that permit the early diagnosis of PRRS and an efficient preventive treatment of such disease.
PRIOR ART
In 1987 it was first detected in North America a swine disease that was defined at that moment as "Mystery Swine Disease" or MSD, and was later known as "Swine Infertility and Respiratory Syndrome", or SIRS. A very similar syndrome was first detected in Central Europe in 1990, and spread later to other European countries, including Spain. At the beginning, in Europe, the disease was named "Porcine Epidemic Abortion and Respiratory Syndrome" or PEARS, and, finally, "Porcine Reproductive and Respiratory Syndrome" or PRRS. This name has become worldwide accepted in reference to the disease.
It is already known that the PRRS etiological agent is a RNA encapsulated small virus, isolated for the first time in The Netherlands, and named as Lelystad virus. It was suggested that this virus belonged to the Arterviridae group. This virus has been described in patent application PCT WO-92/21375 and in European patent EP-B-0587780 (Stichting Centraal Diegeneeskundig Instituut), the latter derived from the former. For the purpose of these applications, an isolate of the above mentioned virus was deposited in the Institut Pasteur of Paris, number I-1102.
The North American type was isolated almost simultaneously with the isolation of the European type virus, as is described in patent application PCT WO-93/03760 (Collins et al.) and European patent application EP-A-0529584 (Boehringer Ing.). For the purpose of these applications, an isolate of the above mentioned virus was deposited in the American Type Culture Collection (ATCC), number VR-2332.
European type and North American type viruses are clearly different, not only in reference to serological reactivity but also relative to the homology degree of nucleotide sequences of significant RNA fragments. In the first two pages of the European patent application EP-A-0676467 (Akzo) there is a detailed description of such differences, with extensive literature citation. In the above mentioned patent application it is concluded that the European type and American type viruses have clearly diverged long time ago. In consequence, it can be expected that eventually effective vaccines against one of these types would be little or no effective at all against the other type.
Different strains have been isolated from both the European and American virus types. Each strain has its own specific characteristics, and several strains have been the object of patent application. For example, patent application PCT WO-93/07898 (Akzo) describes a European strain, and vaccines derived from it, deposited in CNCM (Institut Pasteur), number I-1140. The patent application PCT WO-93/14196 and the European patent application EP-A-541418 (Rhone-Merieux), both derived from the same priority application, describe a new strain isolated in France, deposited in CNCM (Institut Pasteur), number I-1153. The European patent application EP-A-0595436 (Solvay) describes a new American type strain, more virulent than the one initially described, and vaccines thereof. This strain has been deposited in ATCC, but the deposit number is not detailed in the patent application. Finally, Spanish patent application number ES-A-2074950 (Cyanamid Iberica) describes a so-called "Spanish strain", that is different from other European and American strains. This "Spanish strain" has been deposited in European Animal Cell Culture Collection (EACCC), number V93070108.
In conclusion, it appears evident that the PRRS etiological agent shows a number of varieties, and, in order to fight efficiently the disease, vaccines of different types depending on the viral strain type that infe
REFERENCES:
patent: 5476778 (1995-12-01), Chladek et al.
Lager et al, 1995, Second International Symposium on PRRS, Denmark, p. 10 (Abstract Only), Aug. 9, 1995.
G. Labarque, "Efficacy of an American and a European Serotype PRRSV Vaccine After Challenge With American and European Wild-Type Strains of the Virus" P6-C-08, PRRS and Aujeszky's Disease, pp. 251-252.
M. Scortti et al., "Evaluation of the Efficacy of Two Spanish Attenuated-Live Virus Vaccines Against PRRS-Induced Reproductive Disease" P6-P-19, PRRS and Aujeszky's Disease, pp. 291-292.
P.J.G.M. Steverink et al., "Serological Profiles of Pigs Consecutively Challenged With An American and European Strain of the Porcine Reproductive and Respiratory Syndrome Virus" P4-P-08, PRRS and Aujeszky's Disease, pp. 179-180.
Paloma Suarez et al., "Open Reading Frame 5 of Porcine Reproductive and Respiratory Syndrome Virus as a Cause of Virus-Induced Apoptosis" Journal of Virology, vol. 70, May 1996, pp. 2876-2882.
C. Prieto et al., "Transplacental Infection Following Exposure of Gilts to Porcine Reproductive and Respiratory Syndrome Virus at the Onset of Gestation" Veterinary Microbiology, vol. 57, 1997, pp. 301-311.
C. Prieto et al., "Insemination of A Susceptible and Preimmunized Gilts with Boar Semen Containing Porcine Reproductive and Repiratory Syndrome Virus", Theriogenology, vol. 47, 1997, pp. 647-654.
C. Prieto et al., Effect of Innoculating Gilts with Porcine Reproductive and Respiratory Syndrome Virus (PRRSV) Near the Time of Conception, Proceedings of the 14th IPVS Congress, Italy, Jul. 7-10, p. 84.
C. Prieto et al., Effect of Inseminating Susceptible and Preimmunized Gilts with Semen Containing Porcine Reproductive and Respiratory Syndrome Virus (PRRSV) Proceedings of the 14th IPVS Congress, Italy, Jul. 7-10, 1996, p. 83.
C. Prieto et al., "Exposure of Gilts in Early Gestation to Porcine Reproductive and Respiratoy Syndrome Virus" The Veterinary Record, vol. 138, Jun. 1, 1999, pp. 536-539.
P. Suarez et al., "Direct Detection of the Porcine Reproductive and Respiratory Syndrome (PRRS) Virus by Reverse Polymerase Chain Reaction (RT-PCR)" Archives of Virology, vol. 135, 1994, pp. 89-99.
Burch Reina Alemany
Maso Enric Espuna
Pujadas Pere Riera
Roca Narcis Saubi
Laboratorios Hippra, S.A.
Mosher Mary E.
Salimi Ali R.
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