Attenuated smallpox vaccine strain

Chemistry: molecular biology and microbiology – Virus or bacteriophage – except for viral vector or... – Inactivation or attenuation; producing viral subunits

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424 89, C12N 708, A61K 39285

Patent

active

045671478

ABSTRACT:
The present invention discloses an attenuated smallpox vaccine strain exhibiting antibody production similar to conventional strains but without postvaccinal side effects. The vaccine is prepared by attenuating a Lister strain of a vaccinia virus by cell culture and selecting a suitable strain therefrom showing relatively small and uniform pocks on the chorioallantoic membrane of an embryonated egg.

REFERENCES:
patent: 3135661 (1964-06-01), Bartell et al.
patent: 3739065 (1973-06-01), Thorishaus

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