Chemistry: molecular biology and microbiology – Virus or bacteriophage – except for viral vector or... – Inactivation or attenuation; producing viral subunits
Patent
1984-12-20
1986-01-28
Rosen, Sam
Chemistry: molecular biology and microbiology
Virus or bacteriophage, except for viral vector or...
Inactivation or attenuation; producing viral subunits
424 89, C12N 708, A61K 39285
Patent
active
045671478
ABSTRACT:
The present invention discloses an attenuated smallpox vaccine strain exhibiting antibody production similar to conventional strains but without postvaccinal side effects. The vaccine is prepared by attenuating a Lister strain of a vaccinia virus by cell culture and selecting a suitable strain therefrom showing relatively small and uniform pocks on the chorioallantoic membrane of an embryonated egg.
REFERENCES:
patent: 3135661 (1964-06-01), Bartell et al.
patent: 3739065 (1973-06-01), Thorishaus
Hashizume Soh
Morita Michio
Ooi Kiyoshi
Suzuki Kazuyoshi
Yoshizawa Hanako
Chiba Prefectural Government
Rosen Sam
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