Attenuated salmonella SP12 mutants as antigen carriers

Details Attenuated salmonella SP12 mutants as antigen carriers Attenuated salmonella SP12 mutants as antigen carriers

2011-06-07

2011-06-07

Nickol, Gary B. (Department: 1645)

Drug, bio-affecting and body treating compositions

Antigen, epitope, or other immunospecific immunoeffector

C435S007200, C435S007350

Reexamination Certificate

active

07955600

ABSTRACT:
The present invention relates to vaccines, in particular, to an attenuated gram-negative cell comprising the SPI2 gene locus, wherein at least one gene of the SPI2 locus is inactivated, wherein said inactivation results in an attenuation/reduction of virulence compared to the wild type of said cell, and to a carrier for the presentation of an antigen to a host, which carrier is said attenuated gram-negative cell, wherein said cell comprises at least one heterologous nucleic acid molecule comprising a nucleic acid sequence coding for said antigen, wherein said cell is capable of expressing said nucleic acid molecule or capable of causing the expression of said nucleic acid molecule in a target cell.

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