Drug – bio-affecting and body treating compositions – Antigen – epitope – or other immunospecific immunoeffector – Virus or component thereof
Patent
1991-06-28
1998-12-15
Caputa, Anthony C.
Drug, bio-affecting and body treating compositions
Antigen, epitope, or other immunospecific immunoeffector
Virus or component thereof
435691, 4352351, 435237, 435239, 435238, A61K 39255
Patent
active
058492992
ABSTRACT:
A Marek's disease vaccine comprising an attenuated revertant virus derived as a clone of Md11/75/R2 or an antigenic component of the virus is characterized by a markedly reduced pathogenicity compared to the parent virus, without a comparable loss in immunogenicity. Attenuated revertants of the invention are exemplified by Md11/75/R2/23 and Md11/75/R2/29. These viruses or immunogenic components thereof can be formulated into monovalent and polyvalent vaccines.
REFERENCES:
patent: 4673572 (1987-06-01), de Boer
patent: 4895717 (1990-01-01), Witter
R. L. Witter, "Protection by Attenuated and Polyvalent Vaccines Against Highly Virulent Strains of Marek's Disease Virus," Avian Pathol. 11:49-62 (1982).
R. L. Witter et al., "Polyvalent Marek's Disease Vaccines: Safety, Efficacy and Protective Synergism in Chickens with Maternal Antibodies" Avian Pathol. 13: 75-92 (1984).
R. L. Witter, "Attenuated Revertant Serotype 1 Marek's Disease Viruses: Safety and Protective Efficacy" Avian Diseases 35: 877-891 (1991).
Witter, R.L. (87a) Avian Dis. 31:752-765.
Witter, R.L. (87b) Avian Dis. 31:829-840.
Hirai, K. et al. (81) Virology 115:385-389.
Iakovleva, L.S. et al (77) Vopr. Virusol. 4:493-497 (abstract only).
Churchill, A.E. et al. (69) J. Gen. Virol. 4:557-564.
Sharma, J.M. et al. (82) Avian Dis. 26:860-870.
Finkelstein, A. et al. (1989) Trends in Biotechnology 7:273-277.
de Boer, G.F. et al (1987) Vet Q. 9 Suppl. 1 165-285 (abstract only).
Caputa Anthony C.
Fado John D.
Ribando Curtis P.
Silverstein M. Howard
The United States of America as represented by the Secretary of
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