Attenuated respiratory syncytial virus vaccine compositions

Details Attenuated respiratory syncytial virus vaccine compositions Attenuated respiratory syncytial virus vaccine compositions

1995-05-30

1999-03-16

Caputa, Anthony C.

Drug, bio-affecting and body treating compositions

Antigen, epitope, or other immunospecific immunoeffector

Virus or component thereof

4242041, 4352351, 435236, 435237, 435238, 435239, A61K 39155, C12N 704, C12N 706, C12N 708

Patent

active

058826513

ABSTRACT:
The present invention provides vaccine compositions of attenuated respiratory syncytial virus (RSV). More particularly, the attenuated virus may be a derivative of RSV which has been incompletely attenuated by cold-passage or introduction of mutations which produce virus having a temperature sensitive (ts) or cold adapted (ca) phenotype. The invention also provides methods for stimulating the immune system of an individual to induce protection against respiratory syncytial virus by administration of attenuated RSV. The invention also provides pure cultures of attenuated RS virus, wherein the virus has been more completely attenuated by the further derivatization of previously identified incompletely attenuated ts or cp mutants.

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