Drug – bio-affecting and body treating compositions – Lymphokine
Patent
1988-05-11
1991-09-10
Schwartz, Richard A.
Drug, bio-affecting and body treating compositions
Lymphokine
436518, 4351723, 435236, 935 65, 935 81, A61K 39245, G01N 33543, C12N 1538, C12N 1586
Patent
active
050472372
ABSTRACT:
Attenuated pseudorabies viruses are provided which comprise DNA including a sequence essential for replication of the attenuated pseudorabies virus, at least a portion of which is present in a sequence essential for replication of a naturally-occurring pseudorabies virus. The DNA encodes mRNAs which, in an animal infected with the attenuated pseudorabies virus, are translated into antigenic pseudorabies virus gene products which invoke in the infected animal an immunological response distinguishable from an immunological response invoked in an animal infected with a naturally-occurring pseudorabies virus. Also provided are vaccines which comprise the attenuated pseudorabies virus of the present invention and methods of immunizing animals against pesudorabies virus disease.
The invention further provides a method for distinguishing an animal vaccinated with a vaccine of the present invention from an animal infected with a naturally-occuring pseudorabies virus.
REFERENCES:
patent: 4356270 (1982-10-01), Itakura
patent: 4514497 (1985-04-01), Kit et al.
patent: 4810634 (1989-07-01), Pont et al.
Nolan S. L.
PruTech Research and Development Partnership
Schwartz Richard A.
White John P.
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