Chemistry: molecular biology and microbiology – Virus or bacteriophage – except for viral vector or... – Inactivation or attenuation; producing viral subunits
Patent
1993-05-17
1994-03-29
Schwartz, Richard A.
Chemistry: molecular biology and microbiology
Virus or bacteriophage, except for viral vector or...
Inactivation or attenuation; producing viral subunits
4351723, 424 93A, C12N 704, C12N 701, C12N 1509, A61K 3913
Patent
active
052984168
ABSTRACT:
An attenuated enterovirus or rhinovirus, suitable for use as a vaccine, has a reversed base pairing in the part, or in a part corresponding to the part, of the 5' non-coding region of the genome of poliovirus type 3 Leon strain shown below: ##STR1## A suitable attenuated poliovirus has the bases G and C at positions 469 and 534 respectively for a type 1 or type 2 poliovirus or at positions 472 and 537 respectively for a type 3 poliovirus.
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Almond Jeffrey W.
Minor Philip D.
Skinner Michael A.
Young Colin R.
British Technology Group Ltd.
Carter Philip W.
Schwartz Richard A.
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