Attenuated nonsegmented negative-sense RNA viruses with...

Details Attenuated nonsegmented negative-sense RNA viruses with... Attenuated nonsegmented negative-sense RNA viruses with...

2006-10-06

2011-10-11

Parkin, Jeffrey (Department: 1648)

Drug, bio-affecting and body treating compositions

Antigen, epitope, or other immunospecific immunoeffector

Virus or component thereof

C424S199100, C435S236000

Reexamination Certificate

active

08034355

ABSTRACT:
The invention relates to an attenuated non-segmented negative-sense RNA virus characterized by at least one mutation in the L gene wherein the mutation reduces viral replication, the methods of manufacturing and methods of use.

REFERENCES:
patent: 6673572 (2004-01-01), Parks et al.
patent: 6830748 (2004-12-01), Jin et al.
Novella, I. S., et al., 1995, Rapid viral quasispecies evolution: implications for vaccine and drug strategies, Mol. Med. Today 1(5):248-253.
Bilsel, P. A., and S. T. Nichol, 1990, Polymerase errors accumulating during natural evolution of the glycoprotein gene of viscular stomatitis virus Indiana serotype isolates, J. Virol. 64(10):4873-4883.
Müller, R., et al., 1994, Rift valley fever virus L segment: correction of the sequence and possible functional role of newly identified regions conserved in RNA-dependent polymerases, J. Gen. Virol. 75:1345-1352.
Schnell, M. J., and K.-K. Conzelmann, 1995, Polymerase activity of in vitro mutated rabies virus L protein, Virol. 214:522-530.
Smallwood, S., et al., 1999, Mutations in conserved domain II of the large (L) subunit of the Sendai virus RNA polymerase abolish RNA synthesis, Virol. 262:375-383.
Jin, H., and R. M. Elliott, 1992, Mutagenesis of the L protein encoded by Bunyamwera virus and production of monospecific antibodies, J. Gen. Virol. 73:2235-2244.
Grdzelishvili, V. Z., et al., 2005, A single amino acid change in the L-polymerase protein of vesicular stomatitis virus completely abolishes viral mRNA cap methylation, J. Virol. 79(12):7327-7337.
Skiadopoulos, M. H., et al., 1998, Three amino acid substitutions in the L protein of the human parainfluenza virus type 3 cp45 live attenuated vaccine candidate contribute to its temperature-sensitive and attenuation phenotypes, J. Virol. 72(3):1762-1768.
Grdzelishvili et al.; “A Single Amino Acid Change in the L-Polymerase Protein of Vesicular Stomatitis Virus Completely Abolishes Viral mRNA Cap Methylation;” Journal of Virology; vol. 79, No. 12; Jun. 2005; pp. 7327-7337.
International Search Report (PCT/US06/39023); Date of Mailing: May 22, 2007; 1 page.

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