Attenuated mutant newcastle disease virus strains for in ovo...

Details Attenuated mutant newcastle disease virus strains for in ovo... Attenuated mutant newcastle disease virus strains for in ovo...

2007-08-07

2007-08-07

Campell, Bruce R. (Department: 1648)

Chemistry: molecular biology and microbiology

Virus or bacteriophage, except for viral vector or...

Inactivation or attenuation; producing viral subunits

C435S239000, C435S235100, C435S243000

Reexamination Certificate

active

10491375

ABSTRACT:
The present invention relates to new attenuated mutant New Castle's disease La SotaNewcastle disease virus strains suitable for in ovo vaccination of avian species comprising a mutation in the gene sequences encoding the HN and/or F glycoproteins of said virus. Furthermore, the invention relates to a vaccine composition comprising said attenuated mutant Newcastle's disease La Sota virus strain, and to the use thereof for the preparation of a vaccine for in ovo vaccination of avian species against Newcastle's disease.

REFERENCES:
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Seal et al. “Characterization of Newcastle disease virus vaccines by biological properties and sequence analysis of the hemagglutinin-neuraminidase protein gene” Vaccine vol. 14(1996), No. 8, pp. 761-766.
Meulemans, G et al., entitled “Pathogenicity of Antigenic Variants of NewCastle Disease Virus Italian Strain Selected with Monoclonal Antibodies,” Ann Rech Vet 1987 18: 371-374.
Alexander, D. J., entitled “Newcastle disease and other avian paramyxoviruses,” Rev. sci. tech. Off. int. Epiz., 2000, 19 (2), 443-462.

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