Drug – bio-affecting and body treating compositions – Immunoglobulin – antiserum – antibody – or antibody fragment,... – Binds antigen or epitope whose amino acid sequence is...
Patent
1992-09-15
1997-05-27
Mosher, Mary E.
Drug, bio-affecting and body treating compositions
Immunoglobulin, antiserum, antibody, or antibody fragment,...
Binds antigen or epitope whose amino acid sequence is...
4241471, 4242041, 4352351, 435236, 435331, 435339, 5303879, 5303883, A61K 3942, A61K 3912, C12N 704, C12N 518
Patent
active
056329890
ABSTRACT:
Live, attenuated Delaware infectious bursal disease viruses are screened for effectiveness by a monoclonal antibody specific for said Delaware strain. Those which are not bound by the antibody are not or may not be as effective in conferring protection against homologous wild type infectious bursal disease infection. Currently available live, attenuated vaccines do not include a virus having the binding site specified. A monoclonal antibody specific for the Delaware strain also provides a vaccine for passive immunization.
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Virology, vol. 184, issued Sep. 1991, pp. 437-440, F.S.B. Kibenge, et al., "Genome Cloning and Analysis of the Large RNA Segment (Segment A) of a Naturally Avirulent Serotype 2 Infectious Bursal Disease Virus".
Journal of General Virology, vol. 72, issued Aug. 1991, pp. 1835-1843, H.G. Heine, et al., "Sequence Analysis and Expression of the Host-Protective Immunogen VP2 of a Variant Strain of Infectious Bursal Disease Virus Which Can Circumvent Vaccination with Standard Type 1 Strains".
Luetticken Heinrich D.
Snyder David B.
Vakharia Vikram
Mosher Mary E.
University of Maryland
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