Attenuated influenza type A virus vaccine

Details Attenuated influenza type A virus vaccine Attenuated influenza type A virus vaccine

1979-10-16

1981-07-14

Rose, Shep K.

Drug, bio-affecting and body treating compositions

Lymphokine

A61K 39145

Patent

active

042786622

ABSTRACT:
The invention relates to a novel influenza virus strain and to the influenza virus vaccine containing said strain.
The new strain, which is the DNCM No. I-099 strain, is prepared by recombination of the influenza A/PR/8/34 virus strain with the influenza A/California/10/78 (CNCM No. I-098) virus strain.
The vaccine is prepared by allowing the CNCM No. I-099 strain to grow in the allantoic cavity of fertile hen's eggs, harvesting and freeze-drying the yielded virus material.
The strain and the vaccine deriving therefrom are valuable for the immunization against influenza caused by influenza type A (H.sub.1 N.sub.1) virus strains.

REFERENCES:
patent: 3962423 (1976-04-01), Peetermans
patent: 3991179 (1976-11-01), Beare
patent: 4009258 (1977-02-01), Kilbourne
Mayer et al., J. Virology 11(2): 272-278, Feb. 1973.
Florent et al., Arch. Virol. 54: 19-28, (1977).
Oxford et al., Nature 273: 778-779, Jun. 9, 1978.
Hay et al., Develop. Biol. Standard 39: 15-24, (1977).
Rott et al., Negative Strand Virus and the Host Cell, pp. 653-662, (1978), Academic Press.
Rott et al., J. Gen. Virol. 44: 471-477, (1979).
Cox et al., Virology 97: 190-194, (1979).
Boudreault, Can. J. Microbiol. 25: 279-284, (1979).
Murphy et al., IVH Intern. Congr. Virol., (The Hague, 1978).
Yamane et al., Jap. J. Med. Sci. Biol. 31: 431-434, (1978).

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