Attenuated herpesvirus, herpesvirus which include foreign DNA en

Details Attenuated herpesvirus, herpesvirus which include foreign DNA en Attenuated herpesvirus, herpesvirus which include foreign DNA en

1994-11-04

1998-11-10

Guzo, David

Chemistry: molecular biology and microbiology

Vector, per se

536 2372, C12N 1586

Patent

active

058343059

ABSTRACT:
The present invention provides a hybrid, nonprimate herpesvirus comprising DNA which includes a sequence essential for viral replication of the hybrid, nonprimate herpesvirus, at least a portion of which is present in a sequence essential for replication of a naturally-occurring nonprimate herpesvirus and at least one foreign DNA sequence. Also provided is an attenuated, nonprimate herpesvirus comprising DNA which includes a sequence essential for viral replication of the attenuated, nonprimate herpes-virus, at least a portion of which is present in a sequence essential for replication of a naturally-occurring nonprimate herpesvirus, from which at least a portion of a repeat sequence has been deleted. Also provided are vaccines comprising the viruses of the invention and methods of immunizing animals against various disease.

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