Chemistry: molecular biology and microbiology – Virus or bacteriophage – except for viral vector or... – Inactivation or attenuation; producing viral subunits
Patent
1984-05-14
1991-06-04
Rosen, Sam
Chemistry: molecular biology and microbiology
Virus or bacteriophage, except for viral vector or...
Inactivation or attenuation; producing viral subunits
424 89, C12N 708
Patent
active
050213482
ABSTRACT:
Hepatitis A virus is attenuated by propagation in cell culture in vitro by direct inoculation of the cell cultures with a human clinical specimen containing the virus.
REFERENCES:
Feinstone et al., Science, vol. 182 (Dec. 1973), pp. 1026-1028.
Feinstone et al., J. of Virology, vol. 13, No. 6, Jun. 1974, pp. 1412-1414.
Provost et al., PSEB M, vol. 160 (1979), pp. 213-221.
Giesa Paula A.
Hilleman Maurice R.
Provost Philip J.
Merck & Co. , Inc.
Perrella Donald J.
Pfeiffer Hesna J.
Rosen Sam
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