Drug – bio-affecting and body treating compositions – Whole live micro-organism – cell – or virus containing – Genetically modified micro-organism – cell – or virus
Reexamination Certificate
2003-04-03
2008-11-11
Minnifield, N. M (Department: 1645)
Drug, bio-affecting and body treating compositions
Whole live micro-organism, cell, or virus containing
Genetically modified micro-organism, cell, or virus
C424S093100, C424S093400, C424S255100, C424S234100, C424S200100, C424S184100, C424S256100, C435S320100, C435S252300, C435S069100, C435S071100, C536S023100, C536S023700
Reexamination Certificate
active
07449178
ABSTRACT:
Disclosed and claimed are a mutant of a gram negative bacterium, wherein said bacterium has at least one mutation in a nucleotide sequence which codes for a polypeptide having an identity which is equal or more than 70%, 75%, 80%, 85%, 90%, 95%, 96%, 97%, 98%, or 99% with an amino acid sequence coded by a nucleotide sequence selected from the group consisting of nucleotide sequences identified SEQ ID NO: 2, 6, 9, 12, 16, 19, 22, 25, 28, 31, 34, 37, 40, 43, 46, 49, 52, 55, 58, 61, 64, 67, 70, 75, 78, 81, 84, 87, 90, 93; said mutation resulting in attenuated virulence of the bacterium. Immunogenic compositions and vaccines containing such a mutant are also disclosed and claimed.
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Crooke Helen Rachel
Feldman Robert Graham
Goutebroze Sylvain Gabriel
Le Gros Francois-Xavier
Shea Jacqueline Elizabeth
Javecki-Black Judy
Kowalski, Esq. Thomas
Merial Limited
Merial Limited
Minnifield N. M
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