Drug – bio-affecting and body treating compositions – Antigen – epitope – or other immunospecific immunoeffector – Virus or component thereof
Reexamination Certificate
2005-07-12
2005-07-12
Leffers, Gerry (Department: 1636)
Drug, bio-affecting and body treating compositions
Antigen, epitope, or other immunospecific immunoeffector
Virus or component thereof
C424S093200, C435S235100, C435S320100, C435S091100, C435S440000, C435S455000, C435S325000, C536S023100
Reexamination Certificate
active
06916477
ABSTRACT:
The present invention is directed to a method of producing attenuated forms of bovine viral diarrhea (BVD) virus by mutating the Nproprotease gene. The invention includes the attenuated viruses made by this method, antibodies generated using these viruses, and vaccines that can be used for immunizing cattle.
REFERENCES:
patent: 5206163 (1993-04-01), Renard et al.
patent: 62-69991 (1987-03-01), None
Kupfermann, et al. Journal of Virology, 1996, vol. 70, No. 11, pp. 8175-8181.
Collett, Marc S., et al., Proteins Encoded by Bovine Viral Diarrhea Virus: The Genomic Organization of a Pestivirus,Virology, 165, 200-208 (1988).
Vassilev, Ventzislav B., et al., Authentic and Chimeric Full-Length Genomic cDNA Clones of Bovine Viral Diarrhea Virus that Yield Infectious Transcripts,Journal of Virology, vol. 71, No. 1, 471-478 (1997).
Cao Xuemei
Sheppard Michael G.
Kohn Kenneth I.
Kohn & Associates PLLC
Leffers Gerry
Pfizer Inc.
Wootton Thomas A.
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