Attenuated equine herpesvirus

Drug – bio-affecting and body treating compositions – Antigen – epitope – or other immunospecific immunoeffector – Virus or component thereof

Reexamination Certificate

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C424S204100, C435S069100

Reexamination Certificate

active

07060282

ABSTRACT:
The present invention relates to novel Equine herpesvirus (EHV) mutants comprising one or more deletions, substitutions, or insertions in the endogenous promoter region of an essential viral gene, preferably the immediate early gene of EHV. The EHV mutants are stable and have reduced virulence, which makes them very suitable for use in a live vaccine. The invention furthermore relates to live vaccines comprising said EHV mutants, to DNA sequences and vectors harbouring a mutated EHV sequence, to host cells transfected with said DNA or vectors. The invention also relates to a method of attenuating EHV in general, and EHV-1 in particular.

REFERENCES:
patent: WO 92 01045 (1992-01-01), None
patent: WO 96 04394 (1996-02-01), None
Lewis et al., “Transcriptional control of the equine herpesvirus 1 immediate early gene” Virology, vol. 197, No. 2 Dec. 1993, p. 788-792.
Smith et al., “Nuclear localization and transcriptional activation activities of truncated versions of the Immediate-Early gene product of Equine Herpes 1” Journal of Virology, vol. 69 No. 6, Jun. 1995, p. 3857-3862.
Marshall et al., “An Equine Herpesvirus-1 Gene 71 Deletant is Attenuated and Elicits a Protective Immune Response in Mice” Virology, vol. 231, No. 1, p. 20-27.

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