Attachment of second harmonic-active moiety to molecules for...

Chemistry: analytical and immunological testing – Optical result

Reexamination Certificate

Rate now

  [ 0.00 ] – not rated yet Voters 0   Comments 0

Details

C436S501000, C436S518000, C435S006120, C435S007920, C356S300000

Reexamination Certificate

active

06953694

ABSTRACT:
This invention provides methods of detecting molecules at an interface, which comprise labeling the molecules with a second harmonic-active moiety and detecting the labeled molecules at the interface using a surface selective technique. The invention also provides methods for detecting a molecule in a medium and for determining the orientation of a molecular species within a planar surface using a second harmonic-active moiety and a surface selective technique.

REFERENCES:
patent: 5145790 (1992-09-01), Mattingly et al.
patent: 5236826 (1993-08-01), Marshall et al.
patent: 5696157 (1997-12-01), Wang et al.
patent: 5962248 (1999-10-01), Tadano et al.
patent: 6055051 (2000-04-01), Eisenthal et al.
patent: 6180415 (2001-01-01), Schultz et al.
patent: 6194222 (2001-02-01), Buechler et al.
patent: 6456423 (2002-09-01), Nayfeh et al.
patent: 2002/0094528 (2002-07-01), Salafsky
patent: 2002/0127563 (2002-09-01), Salafsky
patent: 0740156 (1996-11-01), None
patent: WO 02/44412 (2002-06-01), None
Conboy et al, Journal of Phsical Chemistry, Studies of Alkane/Water Interfaces by Total Internal Reflection Second Harmonic Generation. 1994, 98, 9688-9692.
Khatchatouriants, A. et al (2000) “GFP Is a Selective Non-Linear Optical Sensor of Electrophysiological Processes inCaenorhabditis elegans,” Biophysical Journal 79:2345-2352 (Exhibit 1),.
Lewis, A. et al (1999) “Second-harmonic generation of biological interfaces: probing the membrane protein bacteriorhodopsin and imaging membrane potential around GFP molecules at specific sites in neuronal cells ofC. elegans.” Chemical Physics 245: 133-144 (Exhibit 2); and.
Peleg, G. et al (1999) “Nonlinear optical measurement of membrane potential around single molecules at selected cellular sites,” Proc. Natl. Acad. Sci. USA 96:6700-6704 (Exhibit 3).
Campagnola, P.J. et al. High-Resolution Nonlinear Optical Imaging of Live Cells by Second Harmonic Generation.Biophysical Journal(1999) 77: 3341-3349.
Eisenthal, K.B. Photochemistry and photophysics of liguid interfaces by second harmonic spectroscopy.J. Phys. Chem. (1996) 100: 12997-13006.
Peleg, G., et al. Nonlinear optical measurement of membrane potential around single molecules at selected cellular sites.Proc. Natl. Acad. Sci. (1999) 96: 6700-6704.
Salafsky, J.S and Eisenthal, K.B. Protein Adsorption at Interfaces Detected by Second Harmonic Generation.J. Phys. Chem. B(2000) 104: 7752-7755.
Salafsky, J.S. and Eisenthal, J.B. Second harmonic spectroscopy: detection and orientation of molecules at a biomembrane interface.Chemical Physical Letters(2000) 319: 435-439.
Srivastava, A. and Eisenthal, K.B. Kinetics of molecular transport across a liposome bilayer.Chemical Physical Letters(1998) 292: 345-351.
European Search Report issued May 18, 2005 in connection with European Patent Application No. 01995403.1
Ditcham, W.G.F. et al., “An immunosensor with potential for the detetion of viral antigens in body fluids, based on...”, Biosensors and Bioelectronics, 16(3):221-224 (2001).
Rinuy, J. et al., “Second harmonic generation of glucose oxidase at the air/water interface”, Biophys. Jour., 77(6):3350-3355 (1999).
Wang, H. et al., “In Situ, Nonlinear Optical Probe of Surfactant Adsorption on the Surface...”, Langmuir, ACS, Washington, DC, US, 16(6):2475-2481 (2000).

LandOfFree

Say what you really think

Search LandOfFree.com for the USA inventors and patents. Rate them and share your experience with other people.

Rating

Attachment of second harmonic-active moiety to molecules for... does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Attachment of second harmonic-active moiety to molecules for..., we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Attachment of second harmonic-active moiety to molecules for... will most certainly appreciate the feedback.

Rate now

     

Profile ID: LFUS-PAI-O-3483642

  Search
All data on this website is collected from public sources. Our data reflects the most accurate information available at the time of publication.