Attachment of proteins to inert particles

Details Attachment of proteins to inert particles Attachment of proteins to inert particles

1977-03-25

1979-02-20

Woodberry, Edward M.

Chemistry of carbon compounds

Miscellaneous organic carbon compounds

195 63, 195 68, 260112R, 424 12, 424 13, 424 78, 424177, A61K 3900, C08L 8900

Patent

active

041406621

ABSTRACT:
A two-step process for achieving a covalent bond between latex polymers and immunological substances, the first of which involves reacting latex particles having a reactive carboxyl group with a diamine in the presence of an appropriate carbodiimide as the condensing agent. The resulting product, which can be designated as the modified latex, is an amide terminating in primary or secondary amino groups. This product is then reacted with the appropriate immunological reagent such as an antigen or antibody modified if necessary to contain amino groups, in the presence of a bifunctional aldehyde to result in the condensation of the amino groups of the immunological reagent to the amino groups of the modified latex via an intermediate aldehyde bridging moiety.

REFERENCES:
patent: 3639558 (1972-02-01), Csizmas
patent: 3788948 (1974-01-01), Kagedal et al.
patent: 3857931 (1974-12-01), Hager
patent: 3959079 (1976-05-01), Mareschi et al.
patent: 4007089 (1977-02-01), Smith
patent: 4045384 (1977-08-01), Dorman

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