Atropisomers of 3-substituted-4-arylquinolin-2-one derivatives

Details Atropisomers of 3-substituted-4-arylquinolin-2-one derivatives Atropisomers of 3-substituted-4-arylquinolin-2-one derivatives

2005-09-06

2005-09-06

Seaman, D. Margaret (Department: 1625)

Organic compounds -- part of the class 532-570 series

Organic compounds

Heterocyclic carbon compounds containing a hetero ring...

C546S157000, C514S312000

Reexamination Certificate

active

06939968

ABSTRACT:
Atropisomers of 3-substituted-4-arylquinolin-2-one derivatives having the general formulawherein R, R1, R2, R3, R4and R5, are as defined herein, or a non-toxic pharmaceutically acceptable salt, solvate or prodrug thereof. The atropisomers can modulate the large conductance calcium-activated K+channels and are useful in the treatment of disorders which are responsive to the opening of the potassium channels. In addition, the atropisomers can be stable, i.e., do not interconvert, for periods of up to one month, or more.

REFERENCES:
patent: 5892045 (1999-04-01), Sit et al.
patent: 5922735 (1999-07-01), Sit et al.
patent: 6184231 (2001-02-01), Hewawasam et al.
patent: 6353119 (2002-03-01), Crispino et al.

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