Atrophy of skin/mucous membrane

Drug – bio-affecting and body treating compositions – Preparations characterized by special physical form – Capsules

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424423, 424434, 424436, 424447, 424449, 424450, 424464, 424DIG15, A61K 948, A61K 920, A61F 202, A61F 902

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active

057470596

ABSTRACT:
The present invention provides novel uses of compounds of general formula I: ##STR1## wherein R.sup.1, R.sup.4 and R.sup.5 are individually hydrogen, hydroxy, halogen, trifluoromethyl, lower alkyl, lower alkoxy or (tertiary amino)(lower alkoxy); and R.sup.2 and R.sup.3 are individually hydrogen or lower alkyl, or as a pharmaceutically acceptable salt thereof in combination with a pharmaceutically acceptable carrier for the manufacture of a pharmaceutical composition for the treatment or prophylaxis of atrophy of skin and/or mucous membranes.

REFERENCES:
patent: 4729999 (1988-03-01), Young
patent: 4894373 (1990-01-01), Young
Drugs of the Future, vol. 20, No. 7, p. 734 (1995).
Paliwal, A. et al, Indian Journal of Experimental Biology, vol. 52, pp. 913-914 (Oct., 1992).
Lal, J. et al., Contraception, Elsevier Science, Inc., vol. 52, pp. 297-300 (1995).

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