Atrial natriuretic peptide derivative

Details Atrial natriuretic peptide derivative Atrial natriuretic peptide derivative

1987-09-25

1992-10-27

Cashion, Jr., Merrell C.

Chemistry: natural resins or derivatives; peptides or proteins;

Peptides of 3 to 100 amino acid residues

15 to 23 amino acid residues in defined sequence

C07K 710

Patent

active

051590611

ABSTRACT:
A peptide derivative of the formula ##STR1## wherein A is hydrogen or a hydrocarbon acyl having 2 to 18 carbon atoms which is substituted by an amino group at the .alpha.-position; B is F-Gly wherein F is a neutral .alpha.-amino acid residue, or NH-(CH.sub.2)nCO wherein n is an integer of 1 to 4; C is a neutral .alpha.-amino acid residue; and E is L-Arg or D-Arg; when A, B and C are hydrogen, Gly-Gly, and Met or Ile, respectively, E is D-Arg, or its pharmacologically acceptable salt has strong hypotensive and natriuretic activity; therefore it is useful as a therapeutic drug for hypertension, a diuretic, and a therapeutic drug for cardiac and cerebral circulatory diseases.

REFERENCES:
patent: 4508712 (1985-04-01), Needleman
patent: 4607023 (1986-08-01), Thibault et al.
patent: 4670540 (1987-06-01), Sakakibara
patent: 4757048 (1988-07-01), Lewicki et al.
Flynn, T. G.; Davies, P. L., Review Article, Biochem. J., 232: 313-321, 1985.
Chino, et al., Peptide Chemistry 1984: N. Izumiya (Ed.), Protein Res. Found., Osaka (1985), pp. 229-235.
Kanagawa et al. Purification and Complete Amino Acid Sequence of a-Human Atrial Natriuretic Polypeptide (a-hANP) "Biochemical and Biophysical Research Communications" vol. 118, No. 1, 1984, Jan. 13, 1984; pp. 131-139.
Chino et al. Synetheses of a-Human Atrial Natriuretic Polypeptide (a-hANP) and Its Peptides "Peptide Chemistry 1984: N. Izumiya (Ed.) Protein Research Foundation Osaka (1985)" pp. 240-247.
Minamitake et al. Syntheses and Biological Activities of a-Human Atrial Natriuretic Polypeptide and Its Analogs "Peptide Chemistry 1984: N. Izumiya (Ed.) Protein Research Foundation, Osaka (1985)" pp. 229-235.
C. M. Deber et al. (Chino) "Structure-Activity Study of -Human Atrial Natriuretic Polypeptide (-haNP)" Proceedings of the Amer. Peptide Symposium, Proc. 9, 1985, pp. 945-948.

Affiliated with

Also associated with

Rating

Atrial natriuretic peptide derivative does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Atrial natriuretic peptide derivative, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Atrial natriuretic peptide derivative will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFUS-PAI-O-906424