Atrial hypotensive peptide

Details Atrial hypotensive peptide Atrial hypotensive peptide

1989-05-09

1991-10-15

Schain, Howard E.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Peptide containing doai

514 13, 530324, 530325, 530326, C07K 710, A61K 3702

Patent

active

050574957

ABSTRACT:
An atrial natriuretic peptide having profound natriuretic, diuretic and hypotensive effects, characterized by a 45 amino acid residue sequence: ##STR1## having a disulphide bond between the cysteine residues which may be extracted from mammalian heart atria is described. A synthetic peptide comprising the above sequence of 45 amino acids and a synthetic 29 amino acid residue peptide corresponding to residues 17-45 of the above sequence both containing a disulfide linkage between the cysteine residues have also been prepared and shown to have similar biological activity as the native peptides. A synthetic 23 amino acid residue peptide corresponding to residues 23-29, which is the disulphide bonded ring portion of the above sequences, has been shown to have biological activity.

REFERENCES:
patent: 4904763 (1990-02-01), Matsuo et al.
Flynn, T. et al., Biochem. and Biophys. Res. Commun., 161(2): 830-837, Jun. 1989.
Flynn, T. et al., Biochem. and Biophys. Res. Commun., 163(2): 1189, Sep. 1989.
Suggs, S. et al., Proc. Natl. Acad. Sci., 78(11): 6613-6617, Nov. 1981.
Vlasuk, G. et al., Biochenm. Biophys. Res. Commun., 136(1): 396-403, Apr. 1986.
Oikawa, S. et al., Biochem. Biophys. Res. Commun., 132(3): 892-899, Nov. 1985.
Kojima, M. et al., Biochem. Biophys. Res. Commun., 159(3): 1420-1426, Mar. 1989.
Sudoh, T. et al., Nature, 332: 78-81, Mar. 1988.
Aburaya, M. et al., Biochem. Biophys. Res. Commun., 163(1): 226-232, Aug. 1989.
Kamayashi, Y. et al., Biochem. Biophys. Res. Commun., 163(1): 233-240, Aug. 1989.

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