Chemistry: molecular biology and microbiology – Micro-organism – tissue cell culture or enzyme using process... – Recombinant dna technique included in method of making a...
Patent
1997-07-15
1999-05-25
Saunders, David
Chemistry: molecular biology and microbiology
Micro-organism, tissue cell culture or enzyme using process...
Recombinant dna technique included in method of making a...
435325, 4353201, 536 235, C12P 2100, C07H 2104, C12N 1515, C12N 510
Patent
active
059069236
ABSTRACT:
The invention provides a novel human ATPase inhibitor protein (HATPI) and polynucleotides which identify and encode HATPI. The invention also provides genetically engineered expression vectors and host cells containing the nucleic acid sequences encoding HATPI. The invention also provides pharmaceutical compositions containing HATPI or antagonists to HATPI, and in the use of these compositions for the treatment of diseases associated with the expression of HATPI. Additionally, the invention provides for the use of antisense molecules to polynucleotides encoding HATPI for the treatment of diseases associated with the expression of HATPI. The invention also provides diagnostic assays which utilize the polynucleotide, or fragments or the complement thereof, to hybridize to the genomic sequence or transcripts of polynucleotides encoding HATPI or anti-HATPI antibodies which specifically bind to HATPI.
REFERENCES:
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Rouslin, Wm. et al., "Regulation of the Mitochondrial Adenosine 5'-Triphosphatase in Situ during Ischemia and in Vitro in Intact and Sonicated Mitochondria from Slow and Fast Heart-Rate Hearts", Arch.Biochem.Biophys. (1990) 280:103-111.
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Billings Lucy J.
Incyte Pharmaceuticals Inc.
Price Leanne C.
Saunders David
VanderVegt F. Pierre
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