Drug – bio-affecting and body treating compositions – Enzyme or coenzyme containing – Hydrolases
Patent
1999-08-11
2000-03-14
Achutamurthy, Ponnathapu
Drug, bio-affecting and body treating compositions
Enzyme or coenzyme containing
Hydrolases
435195, A61K 3846
Patent
active
06036954&
ABSTRACT:
The invention provides a human ATP synthase subunit homolog (ASYNT) and polynucleotides which identify and encode ASYNT. The invention also provides expression vectors, host cells, antibodies, agonists, and antagonists. The invention also provides methods for diagnosing, treating or preventing disorders associated with expression of ASYNT.
REFERENCES:
Belogrudov, G.I. et al., "Membrane Topography and Near-neighbor Relationships of the Mitochondrial ATP Synthase Subunits e, f, and g", J. Biol. Chem. 271(34): 20340-20345 (1996).
Hartzog, P.E. and Cain, B.D., "The a.sub.leu207->arg Mutation in F.sub.1 F.sub.0 -ATP Synthase from Escherichia coli", J. Biol. Chem. 268(17): 12250-12252 (1993).
Sutliff, T.D. et al., (Direct Submission), GenBank Sequence Database (Accession 100657), National Center for Biotechnology Information, National Library of Medicine, Bethesda, Maryland, 20894 (GI 100657), Dec. 6, 1996.
Baughn Mariah R.
Corley Neil C.
Guegler Karl J.
Tang Y. Tom
Achutamurthy Ponnathapu
Incyte Pharmaceuticals Inc.
Muenzen Colette C.
Slobodyansky Elizabeth
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