ATP synthase Fo subunit

Details ATP synthase Fo subunit ATP synthase Fo subunit

1998-12-16

1999-10-05

Degen, Nancy

Chemistry: natural resins or derivatives; peptides or proteins;

Proteins, i.e., more than 100 amino acid residues

C07K 1400

Patent

active

059626461

ABSTRACT:
The present invention provides a human ATP synthase d subunit (ASYSD) and polynucleotides which encode ASYSD. The invention also provides expression vectors, host cells, agonists, antisense molecules, antibodies, or antagonists. The invention also provides to methods for producing ASYSD and for treating disorders associated with expression of ASYSD.

REFERENCES:
Walker, J. et al., "The role of the stalk in the coupling mechanisim of F.sub.1 F.sub.0 -ATPases", FEBS Letters, 346: 39-43 (1994).
Walker, J. et al., "Identification of the subunits of F.sub.1 F.sub.0 -ATPase from bovine heart mitochondria", Biochemistry, 30: 5369-5378 (1991).
Motojima, K., et al., "cDNA cloning for and preparation of antibodies against subunit d of H.sup.+ -ATP synthase in rat mitochondria", Biochem. And Biophys. Res. Commun., 182: 1130-1138 (1992).
Walker, J. et al., "ATP Synthase from Bovine Mitochondria, The charaterization and sequence analysis of two membrane-associated sub-units and of the corresponding cDNAs", J. Mol. Biol., 197: 89-100 (1987).
Database EMBL, European Bioinformatics Institute, Accession No. AA203548, Jan. 30, 1997, Hillier L. et al.: "zx59a08.rl Soares fetal liver spleen 1NFLS S1 Homo sapiens cDNA clone 446774" XP002071206 The WashU-Merck EST Project.
Database EMBL, European Bioinformatics Institute, Accession No. W19605, May 5, 1996, Hillier et al.: "zb32g11.rl Soares oarathyroid tumor NbHPA Homo sapiens cDNA clone 305348" XP002071207 The WashU-Merck EST Project.
Database Genbank, Acc. No. W01415, Apr. 18, 1996, Hillier, et al.: "za73c08.rl Soares fetal lung NbHL19W Homo sapiens cDNA clone 298190 5'" XP002071208 The WashU-Merck EST Project.
Database Genbank, Acc. No. W47097, Oct. 11, 1996, Hillier, et al.:"zc39f03.rl Soares senescent fibroblasts NbHSF Homo sapiens cDNA clone 324701 5'" XP002071209 The WashU-Merck EST Project.
Database Genbank, Acc. No. N44815, Feb. 13, 1996, Hillier, et al.:"yy24h02.rl Homo sapiens cDNA clone 272211 5'" XP002071210 The WashU-Merck EST Project.
Walker, J.E. et al., "Studies of the Gens for ATP Synthases in Eubacteria, Chloroplasts and Mitochondria: Implications for Structure and Function of the Enzyme", Chem. Scr., 27B: 97-105 (1987).
Database EST-STS on MPSRCH, Accession No. AA081285, Oct. 21, 1996.

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