Chemistry: molecular biology and microbiology – Enzyme – proenzyme; compositions thereof; process for... – Hydrolase
Patent
1998-12-04
2000-04-11
Kemmerer, Elizabeth
Chemistry: molecular biology and microbiology
Enzyme , proenzyme; compositions thereof; process for...
Hydrolase
424 946, 530350, 514 12, C12N 914, C07K 1446
Patent
active
060487186
ABSTRACT:
The present invention provides a human mitochondrial F6 subunit (HMF6) and polynucleotides which encode HMF6. The invention also provides expression vectors, host cells, agonists, antisense molecules, antibodies, or antagonists. The invention also provides methods for treating disorders associated with expression of HMF6.
REFERENCES:
Walker, J.E. et al., "The role of the stalk in the coupling mechanism of F.sub.1 F.sub.0 -ATPases" FEBS Lett. 346: 39-43 (1994).
Higuti, T. et al., "cDNA Cloning and Sequencing for the Import Precursor of Coupling Factor 6 in H.sup.+ -ATP Synthase from Rat Liver Mitochondria" Biochem. Biophys. Res. Commun. 171(3) : 1079-1086 (1990).
Walker, J.E. et al., "ATP Synthase from Bovine Mitochondria: Sequences of Imported Precursors of Oligomycin Sensitivity Conferral Protein, Factor 6, and Adenosinetriphosphatase Inhibitor Protein" Biochemistry 26: 8613-8619 (1987) (GI 625323).
Higuti, T. et al., "Molecular Cloning of cDNA for the Import Precursor of Human Coupling Factor 6 of H.sup.+ -ATP Synthase in Mitchondria" Biochem. Biophys. Res. Commun. 178(2) : 793-799 (1991) (GI 183786).
Javed et al., Human mitochaondrial ATP synthase: cloning cDNA for the nuclear precursor of coupling factor 6. GENE< (Jan. 15 1991) 97 (2) 307-310.
Tracer et al., Rat mitochondrial coupling factor 6: molecular cloning of a cDNA encoding the imported precursor. GENE (Jul. 15, 1992) 116 (2) 291-292.
Rocha et al., GenBank Accession No. U77128, Nov. 21, 1996.
Chen et al. Isolation and structural characterization of porcine coupling factor 6 from intestinal tissues. FEBS Lett. (Dec. 1987) 226:43-46.
Sambrook et al. Molecular Cloning: A Laboratory Manual Second Edition vols. 1, 2 and 3, pp. 16.2 and 17.2. Cold Spring Harbor Laboratory Press: Cold Spring Harbor, New York, U.S.A. Nov., 1989.
Niaudet et al. Renal involvement in mitochondrial cytopathies. Pediatric Nephrology, (Jun. 1996) 10 (3) 368-73.
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Hillman Jennifer L.
Shah Purvi
Incyte Pharmaceuticals Inc.
Kemmerer Elizabeth
Mohan-Peterson Sheela
Muenzen Colette C.
Romeo David S.
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