ATP-dependent protease and use of inhibitors for same in the tre

Details ATP-dependent protease and use of inhibitors for same in the tre ATP-dependent protease and use of inhibitors for same in the tre

1994-06-20

1996-10-15

Patterson, Jr., Charles L.

Chemistry: molecular biology and microbiology

Enzyme , proenzyme; compositions thereof; process for...

Hydrolase

435219, C12N 964

Patent

active

055653510

ABSTRACT:
The ATP-ubiquitin-dependent process has been shown to be responsible for the excessive protein degradation which occurs in conditions or disease states in which there is severe loss of body mass and negative nitrogen balance has been identified and key constituents in the process identified. A method of inhibiting the accelerated or enhanced proteolysis, a method of identifying inhibitors of the process, multipain and the proteasome inhibitor are the subject of the claimed invention.

REFERENCES:
patent: 5340736 (1994-08-01), Goldberg
Driscoll, J., and Goldberg, A. L., "Skeletal muscle proteasome can degrade proteins in an ATP-dependent process that does not require ubiquitin", Proc. Natl. Acad. Sci. USA 86:787-791 (Feb. 1989).
Eytan, E., et al., "ATP-dependent incorporation of 20S protease into the 26S complex that degrades proteins conjugated to ubiquitin", Proc. Natl. Acad. Sci. USA 86:7751-7755 (Oct. 1989).
Fagan, J. M., and Waxman, L., "A Novel ATP-requiring Protease from Skeletal Muscle That Hydrolyzes Non-ubiquitinated Proteins", J. Biol. Chem. 264(30):17868-17872 (Oct. 25,1989).
Kettelhut, I. C., et al., "Endocrine Regulation of Protein Breakdown in Skeletal Muscle", Diabetes/Metabolism Reviews 4(8):751-772 (1988).
Llovera, M., et al., "Muscle Wasting Associated with Cancer Cachexia is Linked to an Important Activation of the ATP-Dependent Ubiquitin-Mediated Proteolysis", Int. J. Cancer 61:138-141 (1995).
Mason, R. W., "Characterization of the active site of human multicatalytic proteinase", Biochem. J. 265(2):479-484 (Jan. 15, 1990).
McGuire, M. J., and DeMartino, G. N., "The Latent Form of Macropain (High Molecular Weight Multicatalytic Protease) Restores ATP-Dependent Proteolysis to Soluble Extracts of BHK Fibroblasts Pretreated with Anti-Macropain Antibodies", Biochem. Biophys. Res. Commun. 160(2):911-916 (Apr. 28, 1989).
Medina, R., et al., "Activation of the ubiquitin-ATP-dependent proteolytic system in skeletal muscle during fasting and denervation atrophy", Biomed. Biochim. Acta 50(4-6):347-356 (Apr.-Jun. 1991).
Orlowski, M., and Michaud, C., "Pituitary Multicatalytic Proteinase Complex. Specificity of Components and Aspects of Proteolytic Activity", Biochemistry 28:9270-9278 (1989).
Orlowski, M., et al., "Regulation of the Peptidylglutamyl-Peptide Hydrolyzing Activity of the Pituitary Multicatalytic Proteinase Complex", Biochemistry 30(24):5999-6005 (Jun. 18, 1991).
Riley, D. A., et al., "Quantitation and Immunocytochemical Localization of Ubiquitin Conjugates Within Rat Red and White Skeletal Muscles,"P J. Histochem. Cytochem. 36(6):621-632 (1988).
Chu-Ping et al., "Purification and characterization of a protein inhibitor of the 20S proteasome (macropain)", Biol. Abstr. 93: Abstract No. 130496 (1992).
Ciechanover & Schwartz, "How are substrates recognized by the ubiquitin-mediated proteolytic systems?", TIBS 14:483-488 (Dec. 1989).
Dahlmann et al., "ATP-activated, high-molecular-mass proteinase-I from rat skeletal muscle is a cysteine proteinase-.alpha..sub.1 -macroglobulin complex", Biochim. et Biophys. Acta 991:253-262 (1989).
Driscoll & Goldberg, "The Proteasome (Multicatalytic Protease) Is a Component of the 1500-kDa Proteolytic Complex Which Degrades Ubiquitin-conjugated Proteins", J. Biol. Chem. 265:4789-4792 (Mar. 25, 1990).
Etlinger & Goldberg, "A soluble ATP-dependent proteolytic system responsible for the degradation of abnormal proteins in reticulocytes", Proc. Natl. Acad. Sci. USA 74:54-58 (Jan. 1977).
Fagan et al., "Red Blood Cells Contain a Pathway for the Degradation of Oxidant-damaged Hemoglobin That Does Not Require ATP or Ubiquitin", J. Biol. Chem. 261:5705-5713 (May 5, 1986).
Fagan et al., "Skeletal muscle and liver contain a soluble ATP+ ubiquitin-dependent proteolytic system", Biochem. J. 243:335-343 (Apr. 15, 1987).
Furuno et al., "Role of Different Proteolytic Systems in the Degradation of Muscle Proteins during Denervation Atrophy", J. Biol. Chem. 265:8550-8557 (May 25, 1990).
Ganoth et al., "A Multicomponent System That Degrades Proteins Conjugated to Ubiquitin", J. Biol. Chem. 263:12412-12419 (Sep. 5, 1988).
Han et al., "Activation of the ATP-Dependent Proteolytic System In Skeletal Muscle During Denervation Atrophy and Fasting", FASEB Abstr. No. 1558 (May 1988).
Hershko et al., "Immunochemical Analysis of the Turnover of Ubiquitin-Protein Conjugates in Intact Cells", J. Biol. Chem. 257:13964-13970 (Dec. 10, 1982).
Kuehn et al., "High-molecular-mass proteinases in rabbit reticulocytes: the multicatalytic proteinase is an ATP-independent enzyme and ATP-activated proteolysis is in part associated with a cysteine proteinase complexed to .alpha..sub.1 -macroglobulin", Biochim. et Biophys. Acta 991:263-271 (1989).
Lowell et al., "Evidence that lysosomes are not involved in the degradation of myofibrillar proteins in rat skeletal muscle", Biochem. J. 234:237-240 (1986).
Matthews et al., "Involvement of the proteasome in various degradative processes in mammalian cells", Proc. Natl. Acad. Sci. USA 86:2597-2601 (Apr. 1989).
Murakami & Etlinger, "Endogenous inhibitor of nonlysosomal high molecular weight protease and calcium-dependent protease", Proc. Natl. Acad. Sci. USA 83:7588-7592 (Oct. 1986).
Sun et al., "Isolation and characterization of ATP-dependent proteolytically active ubiquitin in cock testis", Biol. Abstr. 87: Abstr. No. 98518 (1989).
Okada et al., "Identification of a ubiquitin- and ATP-dependent protein degradation pathway in rat cerebral cortex", Biochim. et Biophys. Acta 1073:514-520 (Apr. 9, 1991).
Reckelhoff & McGuire, "The cytosolic multicatalytic protease, macropain, is found in cultured rat glomerular mesangial cells (MSC)", FASEB J. 5: Abstr. No. 6028 (Mar. 15,1991).
Bachmair, A. et al. (1986) Science 234, 179-186.
Gonda, D. K. et al. (1989) J. Biol. Chem. 264(28), 16700-16712.

Affiliated with

Also associated with

Rating

ATP-dependent protease and use of inhibitors for same in the tre does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with ATP-dependent protease and use of inhibitors for same in the tre, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and ATP-dependent protease and use of inhibitors for same in the tre will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFUS-PAI-O-1245264