ATP-dependent protease and use of inhibitors for same in the tre

Details ATP-dependent protease and use of inhibitors for same in the tre ATP-dependent protease and use of inhibitors for same in the tre

1997-12-02

1999-10-26

Patterson, Jr., Charles L.

Chemistry: molecular biology and microbiology

Measuring or testing process involving enzymes or...

Involving hydrolase

435226, 514 12, 514410, 514423, 514512, C12Q 137

Patent

active

059726369

ABSTRACT:
The ATP-ubiquitin-dependent process has been shown to be responsible for the excessive protein degradation which occurs in conditions or disease states in which there is severe loss of body mass and negative nitrogen balance has been identified and key constituents in the process identified. A method of inhibiting the accelerated or enhanced proteolysis, a method of identifying inhibitors of the process, multipain and the proteasome inhibitor are the subject of the claimed invention.

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