ATP-dependent protease and use of inhibitors for same in the tre

Details ATP-dependent protease and use of inhibitors for same in the tre ATP-dependent protease and use of inhibitors for same in the tre

1991-05-13

1994-08-23

Patterson, Jr., Charles L.

Chemistry: molecular biology and microbiology

Enzyme , proenzyme; compositions thereof; process for...

Hydrolase

435219, C12N 964

Patent

active

053407369

ABSTRACT:
The ATP-ubiquitin-dependent process has been shown to be responsible for the excessive protein degradation which occurs in conditions or disease states in which there is severe loss of body mass and negative nitrogen balance has been identified and key constituents in the process identified. A method of inhibiting the accelerated or enhanced proteolysis, a method of identifying inhibitors of the process, multipain and the proteasome inhibitor are the subject of the claimed invention.

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