ATP-binding cassette protein responsible for cytotoxin...

Chemistry: natural resins or derivatives; peptides or proteins; – Proteins – i.e. – more than 100 amino acid residues

Reexamination Certificate

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C530S389100, C536S023100, C536S023500

Reexamination Certificate

active

07138493

ABSTRACT:
This invention provides for a novel ATP-binding cassette protein which is responsible for cytotoxin resistance. The invention also provides for methods of expressing the protein and assays for identification of inhibitors of the protein.

REFERENCES:
patent: 6313277 (2001-11-01), Ross et al.
patent: WO 98/55614 (1998-12-01), None
patent: 04110 (1999-08-01), None
patent: WO 99/40110 (1999-08-01), None
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Lee et al., “Reduced Drug Accumulation and Multidrug Resistance in Human Breast Cancer Cells Without Assocaited P-Glycoprotein or MRP Overexpression”,Journal of Cellular Biochemistry65: 513-526 (1997).
Doyle et al., “Cloning and characterization of Breast Cancer Resistatance Protein (BCRP), a novel ATP-binding cassette (ABC) transporter that may contribute to the multidrug-resistance phenotype of MCF-7/AdrVp breast cancer cells”,Proceedings of the American Association for Cancer Research39: 657 (1998).
Lage et al., “Cloning and characterization of human cDNAs encoding a protein with high homology to rat intestinal development protein OCI-5”,Gene188: 151-156 (1997).
Bruin et al., “Reversal of resistance by GF120918 in cell lines expressing the ABC half-transporter, MXR”,Cancer letters146: 117-126 (1999).
Miyake et al., “Molecular Cloning of cDNAs Which are Highly Overexpressed in Mitoxantrone-resistant cells: Demonstration of Homology to ABC Transport Genes”,Cancer Research59: 8-13 (1999).
Allikmets et al., “A Human Placenta-specific ATP-Binding Cassette Gene (ABCP) on Chromosome 4q22 That is Involved in Multidrug Resistance”,Cancer Research58: 5337-5339 (1998).
Doyle et al., “A multidrug resistance transporter from human MCF-7 breast cancer cells”,Proc. Natl. Acad. Sci. USA95: 15665-15670 (1998).

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