Atoxic, immunogenic product of tetanus toxin

Details Atoxic, immunogenic product of tetanus toxin Atoxic, immunogenic product of tetanus toxin

1978-12-21

1980-04-29

Rose, Shep K.

Drug, bio-affecting and body treating compositions

Whole live micro-organism, cell, or virus containing

Genetically modified micro-organism, cell, or virus

A61K 3908

Patent

active

042006279

ABSTRACT:
What is disclosed is a method for obtaining an atoxic, immunogenic product from tetanus toxin by treating tetanus toxin with a proteinase. The product, which is different from known fragment C of tetanus toxin, can be used for making a vaccine.

REFERENCES:
Helting, T. B., Zwisler, O. J. Biol. Chem. 252(1):187-193, 10 Jan. 1977, Structure of Tetanus Toxin I. Breakdown of the Toxin Molecule and Discrimination Between Polypeptide Fragments.
Helting, T. B., Zwisler, O. Wiegant, H. 252(1):194-198, 10 Jan. 1977, Structure of Tetanus Toxin II. Toxin Binding to Ganglioside.
Helting, T. B., Ronneberger, H. J., Vollerthun, R., Neubauer, V. J., Biol. Chem. 253(1):125-129, 10 Jan. 1978, Toxicity of Papain--Digested Tetanus Toxin. Pathological Effect of Fragment B in the Absence of Spastic Paralysis.
Helting T., Zwisler, O., Biochem. Biophysres Commun. 57(4) 1974: 1263-1270, Enzymatic Breakdown of Tetanus Toxin.
Helting, T., Zwisler, O., Abstr. Annu. Meet Am Soc. Microbiol. 77 1977 16 Analysis of the Protective Immune Response to Papain Digestion Products of Tetanus Toxin.

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