Atomizing dispenser for endonasal drug spray administration

Details Atomizing dispenser for endonasal drug spray administration Atomizing dispenser for endonasal drug spray administration

1994-06-17

1996-03-26

Kashnikow, Andres

Dispensing

With discharge assistant

Container with follower

239320, G01F 1100

Patent

active

055013732

DESCRIPTION:

BRIEF SUMMARY
BACKGROUND OF THE INVENTION

In the pharmaceutical field, specific packs for endonasal atomized administration of drugs have been developed for single use and for multiple use. These container/dispenser packs are all manually actuated by the user's depression of a slider. This slider requires a rapid, strong action, otherwise the spray jet is not properly atomized.
This rapid and strong action is not achievable by certain patients. Therefore the drug is not properly delivered and looses its effectiveness.
Furthermore, in using single-use packs, which are now very popular due to the easier calculation of the number of administrations in a given time period, it is impossible to spread the delivery into two administrations, one for each nostril. However, this subdivided delivery is the most effective and, therefore, the most advisable.
Thus the administration of these drugs requires 1) the calculation of the number of deliveries in a time period, 2) the delivery of each administration subdivided between the two nostrils and 3) a perfect atomization independent from the speed and strength of the user's actuation of the dispenser.
Known multiple-use devices solve the twin-delivery problem, the single-use devices solve the calculation problem, but neither of the two solves the atomization problem. Thus, to facilitate dispenser use and to avoid incorrect delivery, a spray dispenser able to provide a drug administration subdivided into two half deliveries, one for each nostril, combined with an easier activation of the atomizing device is required. That is, a partially servo-assisted atomization that is not completely dependent on the speed and the strength of the user's action is required. This need has suggested a study of the problem to develop a twin-dose dispenser or, better, one providing a subdivided administration, first into one nostril and then into the other, with means to improve and assure atomization.


SUMMARY OF THE INVENTION

This study has been completed. The result is very satisfactory, both from the use and from the production cost point of view, and the features and the details of the dispenser pack that resulted are described below.
The container/dispenser pack for drugs requiring atomized endonasal administration comprises a main body acting, as usual, as a slider and provided with radial, planar grip extensions for two finger tips of the user's hand. The slider incorporates in its upper part the atomizing nozzle and in its lower part a protruding cylindrical neck within which is an axially slidable cup-shaped housing, which acts as a control button adapted to be pressed by the user's thumb tip.
Said cup-shaped housing encloses a cylindrical drug solution container incorporating an axially-slidable piston/pump comprising a stem provided with two separate, slotted grooves with respective concave bottoms, said grooves each being adapted to receive a resilient detent ring having a radial cut. These two resilient detent rings, which can, under the force exerted by the user's fingers, snap out from their receiving grooves, one after the other, control the piston run, breaking it into two half runs in the case of the twin-use version.
Furthermore, the slight effort required to make each of the two resilient detent rings snap out from their seats accumulates the correct amount energy in the user's fingers, which is instantly released as each snaps out to provide the right speed of activation for the best atomization in any condition.
Thus, an endonasal spray dispenser in accordance with the present invention comprises a pump chamber having radial extensions for gripping and pressing the dispenser and a piston axially slidable in the pump chamber. The pump chamber is tubular and has an opening at the lower end for receiving the piston, and is in fluid connection with an atomizing nozzle at the upper end of the chamber. The dispenser further comprises a detent adapted to resist the axial sliding of the chamber pst a given point along the piston. This detent cooperates with the piston and with the cha

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patent: 4946069 (1990-08-01), Fuchs
patent: 4962868 (1990-10-01), Borchard
patent: 5257726 (1993-11-01), Graf et al.
patent: 5289818 (1994-03-01), Citterio et al.

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