Chemistry: natural resins or derivatives; peptides or proteins; – Proteins – i.e. – more than 100 amino acid residues – Albumin
Reexamination Certificate
2007-04-24
2007-04-24
Lukton, David (Department: 1654)
Chemistry: natural resins or derivatives; peptides or proteins;
Proteins, i.e., more than 100 amino acid residues
Albumin
C530S363000, C540S145000, C540S201000, C378S073000
Reexamination Certificate
active
10506043
ABSTRACT:
A high resolution structure of the hemalbumin binding complex is provided which includes the detailed atomic coordinates which reflect the binding site and the binding characteristics of the structure. This high resolution structure can be used in methods of determining the primary residues involved in gas binding, redox potential of iron, etc., and thus will be used to identify and optimize the gas binding characteristics of heme and albumin, so as to allow for the development of modified recombinant albumins containing heme and/or heme derivatives which have improved gas binding properties and which can be used for therapeutic purposes.
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Wardell, Mark, Biochem. Biophys. Res. Commun. 291(4), 813-819, 2002.
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Komatsu, J Am Chem Soc 126, 14304, 2004.
Carter Daniel C.
Ho Joseph
Wang Zhong Min
Lukton David
New Century Pharmaceuticals Inc.
Schulman B. Aaron
Stites & Harbison PLLC
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