Radiant energy – Ionic separation or analysis – With sample supply means
Reexamination Certificate
2006-06-06
2008-12-09
Berman, Jack I (Department: 2881)
Radiant energy
Ionic separation or analysis
With sample supply means
Reexamination Certificate
active
07462826
ABSTRACT:
An apparatus and method for performing mass spectroscopy uses an ion interface to provide the function of removing undesirable particulates from an ion stream from an atmospheric pressure ion source, such as an electrospray source or a MALDI source, before the ion stream enters a vacuum chamber containing the mass spectrometer. The ion interface includes an entrance cell with a bore that may be heated for desolvating charged droplets when the ion source is an electrospray source, and a particle discrimination cell with a bore disposed downstream of the bore of the entrance cell and before an aperture leading to the vacuum chamber. The particle discrimination cell creates gas dynamic and electric field conditions that enables separation of undesirable charged particulates from the ion stream.
REFERENCES:
patent: 4023398 (1977-05-01), French et al.
patent: 4531056 (1985-07-01), Labowsky et al.
patent: 4746794 (1988-05-01), French et al.
patent: 4842701 (1989-06-01), Smith et al.
patent: 4861988 (1989-08-01), Henion et al.
patent: 4885076 (1989-12-01), Smith et al.
patent: 4977320 (1990-12-01), Chowdhury et al.
patent: 5015845 (1991-05-01), Allen et al.
patent: 5036195 (1991-07-01), Batey et al.
patent: 5103093 (1992-04-01), Sakairi et al.
patent: 5171990 (1992-12-01), Mylchreest et al.
patent: 5270542 (1993-12-01), McMurry et al.
patent: 5298744 (1994-03-01), Mimura et al.
patent: 5304798 (1994-04-01), Tomany et al.
patent: 5313061 (1994-05-01), Drew et al.
patent: 5353892 (1994-10-01), Lu
patent: 5412208 (1995-05-01), Covey et al.
patent: 5565679 (1996-10-01), Tanner et al.
patent: RE35413 (1996-12-01), Mylchreest et al.
patent: 5756994 (1998-05-01), Bajic
patent: 6124675 (2000-09-01), Bertrand et al.
patent: 6177669 (2001-01-01), Wells et al.
patent: 6339218 (2002-01-01), Kato et al.
patent: 6462336 (2002-10-01), Bajic
patent: 6700119 (2004-03-01), Giles
patent: 7098452 (2006-08-01), Schneider et al.
patent: 2003/0062474 (2003-04-01), Baranov et al.
patent: 2004/0262512 (2004-12-01), Tobita et al.
patent: 0 622 830 (1994-11-01), None
patent: 1 193 730 (2002-04-01), None
patent: 2 324 906 (1998-11-01), None
patent: 11-108894 (1999-04-01), None
patent: 2000-55880 (2000-02-01), None
Niessen, “Advances in instrumentation in liquid chromatography-mass spectrometry and related liquid-introduction techniques,”Journal of ChromatographyA.794 (1998) pp. 407-435.
Zubarev et al.,Electron Capture Dissociation of Multiply Charged Protein Cations. A Nonergodic Process; 1998 American Chemical Society, 120, 3265-3266.
Lee et al.,Thermally Assisted Electrospray Interface for Liquid Chromatography/Mass Spectrometry; Rapid Communications in Mass Spectrometry, vol. 6, 727-733 (1992).
Herron et al.,Reactions of Polyatomic Dianions with Cations in the Paul Trap, Rapid Communications in Mass Spectrometry, vol. 10, 277-281 (1996).
Schneider et al.,Atmospheric Pressure Charged Particle Discrimination Interface for Low Flow Rate ESI-MS—ASMA Abstract, no date given.
Schneider et al.,Particle Discriminator Interface for Nanoflow ESI-MS2003 American Society for Mass Spectrometry.
Covey Thomas R.
Schneider Bradley
Berman Jack I
MDS Sciex
Rauschenbach Kurt
Rauschenbach Patent Law Group, LLC
LandOfFree
Atmospheric pressure charged particle discriminator for mass... does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with Atmospheric pressure charged particle discriminator for mass..., we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Atmospheric pressure charged particle discriminator for mass... will most certainly appreciate the feedback.
Profile ID: LFUS-PAI-O-4041756