Radiant energy – Ionic separation or analysis – Cyclically varying ion selecting field means
Reexamination Certificate
2007-12-25
2007-12-25
Kim, Robert (Department: 2881)
Radiant energy
Ionic separation or analysis
Cyclically varying ion selecting field means
C250S292000, C250S288000, C250S290000, C250S299000, C250S3960ML, C250S397000
Reexamination Certificate
active
11135769
ABSTRACT:
The present invention relates to an apparatus and method for focusing, separating, and detecting gas-phase ions using the principles of electrohydrodynamic quadrupole fields at high pressures, at or near atmospheric pressure. Ions are entrained in a concentric flow of gas and travel through a high-transmission element into a RF/DC quadrupole, exiting out of the RF/DC quadrupole, and then impacting on an ion detector, such as a faraday plate; or through an aperture or capillary tube with subsequent identification by a mass spectrometer. Ions with stable trajectories pass through the RF/DC quadrupole while ions with unstable trajectories drift off-axis collide with the rods and are lost. Alternatively, detection of ions with unstable trajectories can be accomplished by allowing the ions to pass through the rods and be detected by an off-axis detector. Embodiments of this invention are devices and methods for focusing, separating, and detecting gas-phase ions at or near atmospheric pressure, when coupled to mass spectrometers.
REFERENCES:
patent: 3935452 (1976-01-01), Prince
patent: 4540884 (1985-09-01), Stafford et al.
patent: 5420424 (1995-05-01), Carnahan et al.
patent: 5420425 (1995-05-01), Bier et al.
patent: 5521380 (1996-05-01), Wells et al.
patent: 5521382 (1996-05-01), Tanaka et al.
patent: 6107628 (2000-08-01), Smith et al.
patent: 6124592 (2000-09-01), Spangler
patent: 6177668 (2001-01-01), Hager
patent: 6495823 (2002-12-01), Miller et al.
patent: 6512224 (2003-01-01), Miller et al.
patent: 6534764 (2003-03-01), Verentchikov et al.
patent: 6621077 (2003-09-01), Guevremont et al.
patent: 6690004 (2004-02-01), Miller et al.
patent: 6700120 (2004-03-01), Hager
patent: 6703607 (2004-03-01), Stott et al.
patent: 6713757 (2004-03-01), Tanner et al.
patent: 6730904 (2004-05-01), Wells
patent: 6781117 (2004-08-01), Willoughby et al.
patent: 6784424 (2004-08-01), Willoughby et al.
patent: 6797950 (2004-09-01), Schwartz et al.
patent: 6806463 (2004-10-01), Miller et al.
patent: 6815668 (2004-11-01), Miller et al.
patent: 6815669 (2004-11-01), Miller et al.
patent: 6818889 (2004-11-01), Sheehan et al.
patent: 6838662 (2005-01-01), Bateman et al.
patent: 6914243 (2005-07-01), Sheehan et al.
patent: 6943347 (2005-09-01), Willoughby et al.
patent: 6949740 (2005-09-01), Sheehan et al.
patent: 6972407 (2005-12-01), Miller et al.
patent: 7081621 (2006-07-01), Willoughby et al.
patent: 2003/0132380 (2003-07-01), Miller et al.
patent: 2004/0094704 (2004-05-01), Miller et al.
patent: 2004/0124354 (2004-07-01), Bateman et al.
patent: 2005/0092918 (2005-05-01), Smith et al.
patent: 2005/0258361 (2005-11-01), Whitehouse et al.
Miller, P.E., et al., “The quadrupole mass filter: Basic operating concepts,” J. Chem. Ed. 63, pp. 617-622 (1986).
Steel, C., et al., “Understanding the quadrupole mass filter through computer stimulations,” J. Chem. Ed. 75, pp. 1049-1054 (1998).
Hill, H.H., et al., “Ion mobility spectrometry,” Anal. Chem. 62, pp. 1201A-1209A (1990).
Johnson, J.V., et al., “The stretched quadrupole ion trap: Implications for the Mathieu . . . ,” Rapid Commun. Mass Spectrom. 6, pp. 760-764 (1992).
Buryakov, I.A., et al. “A New method of separation of multi-atomic ions by mobility at atomospheric . . . ,” Int. J. Mass Spectrom. Ion Processes 128, pp. 143-148 (1993).
Wittmer, D., et al., “Electrospray ionization ion mobility spectrometry,” Anal. Chem. 66, pp. 2348-2355 (1994).
Thomson, B.A., et al., “Improved collisionally activated dissociation efficiemcy and mass resolution on a triple quadrupole . . . ”, J. Anal. Chem. 67, pp. 1696-1704 (1995).
Thomson, B., et al., “RF-only quadrupole with axial fields”, Proceedings of the 44th ASMS Conference on Mass Spectrometry and Allied . . . , May 12-17, 1996, Portland, OR.
Wyttenbach, T., et al., “Gas-phase conformation of biological molecules: Bradykinin,” J. Am. Chem. Soc. 118, pp. 8355-8364 (1996).
Guevremont, R., et al., “Ion mobility / TOF mass spectrometrometric investigation of ions . . . ,” Proceedings of the 45th ASMS Conference, Jun. 1-5, 1997, Palm Springs, CA.
Titov, V.V., “Detailed study of the quadrupole mass analyzer operating within the first, second, and third . . . ,” J. Am. Soc. Mass Spectrometry 9, pp. 50-69 (1998).
Purves, R.W., et al., “Electrospray ionization high-field asymmetric waveform ion mobility spectrometry-mass spectrometry,” Anal. Chem. 71, pp. 2346-2357 (1999).
Ells, B., et al., “Detection of chlorinated and brominated byproducts of drinking water disinfection using electrospray . . . ,”Anal. Chem. 71, pp. 4747-4752 (1999).
Covey, T., et al., “Collision cross sections for protein ions,” J. Am. Soc. Mass Spectrometry 4 , pp. 616-623 (1993).
Stafford, Jr., G., “Ion trap mass spectrometry: A personal perspective,” J. Am. Soc. Mass Spectrometry 13 , pp. 589-596 (2002).
Sheehan Edward William
Willougbhy Ross Clark
Chem - Space Associates, Inc.
Kim Robert
Souw Bernard
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