Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Having -c- – wherein x is chalcogen – bonded directly to...
Reexamination Certificate
2007-05-01
2007-05-01
Barts, Samuel (Department: 1621)
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Having -c-, wherein x is chalcogen, bonded directly to...
C514S408000, C514S519000, C514S661000, C546S195000, C548S528000, C558S429000, C564S453000
Reexamination Certificate
active
10471025
ABSTRACT:
The present invention provides a novel compound exhibiting an excellent suppressing effect to cell injury caused by radicals and neurotoxicity induced by excitatory nuerotransmitters such as glutamate. Specifically, it provides a compound represented by the following formula, a salt thereof or a hydrate of them.Wherein Z represents a bivalent organic group and the like of from 2 to 3 carbon atom(s) which may have a substituent; and R3represents a carboxyl group and the like.
REFERENCES:
Zalkow et al (“The Synthesis of 5a,8,8-Trimethyl-3, 10a-ethnaeoperhydrophenanthrene Terpenes”, Journal of Organic Chemistry 28(8), pp. 2037-2039).
Kume et al (“Isolation of diterpenoid substance with potent neuroprotective activity from fetal calf serum”, PNAS, Feb. 26, 2002).
Toshiaki Kume et al.; Proceedings of the National Academy of Sciences of the United States of America, vol. 99, No. 5, pp. 3288-3293, Mar. 5, 2002.
Russell A. Bell et al.; Tetrahedron Letters, No. 4, pp. 269-273, 1963.
K.M. Baker et al.; Journal of the Chemical Society, Perkin Transactions, 1972, pp. 190-194.
Robert M. Coates et al.; Journal of Organic Chemistry, vol. 36, No. 18, pp. 2625-2631, 1971.
Michael H. Beale et al.; Phytochemistry, vol. 22, No. 4, pp. 875-881, 1983.
Masataka Ihara et al.; Journal of the Chemical Society, Perkin Transactions 1: Organic and Bio-organic Chemistry (1986), (12), pp. 2151-2161.
Georgette Hugel et al.; Bulletin de la Societe Chimique de France, pp. 2894-2902, 1965.
L.H. Zalkow et al.; J. Chem. Soc., Suppl. No. 1, pp. 5497-5503, 1964.
S.W. Pelletier et al.; Chemical Communications, No. 15, pp. 830-831, 1968.
Jan St. Pyrek; Journal of Natural Products, vol. 47, No. 5, pp. 822-827, Sep.-Oct. 1984.
Alan J. McAlees et al.; J. Chem. Soc., Perkin Trans. 1, 1975, No. 9, pp. 861-869.
Helen Margaret Campbell et al.; Can. J. Chem., 1975, vol. 53, No. 1, pp. 20-25.
Russell A. Bell et al.; J. Org. Chem., 1966, vol. 31, No. 8, pp. 2536-2542.
Dennis W. Choi; Trends Neurosci., 11, pp. 465-469, 1988.
Brian Meldrum et al.; Trends Pharmacol. Sci., 11, pp. 379-387, 1990.
Toshiaki Kume et al.; Jpn. J. Pharmacol. vol. 73, pp. 371-374, 1997.
G. Topcu et al.; Phytochemistry, vol. 30, No. 7, pp. 2412-2413, 1991.
Mariano Pinar et al.; Journal of Natural Products, vol. 49, No. 2, pp. 334-335, Mar.-Apr. 1986.
M. Isabel Carrascal et al.; Anales De Quimica; 1977, vol. 73, No. 3, pp. 442-444.
Martin Benoit Ngassoum et al.; J. Essent. Oil Res., vol. 11, No. 3, pp. 283-288, 1999.
Braulio M. Fraga et al.; Biochemical Systematics and Ecology, vol. 23, No. 7/8, pp. 835-842, 1995.
Yi-Li Ding et al.; Phytochemistry, 1991, vol. 30, No. 7, pp. 2413-2415.
Braulio M. Fraga et al.; Phytochemistry, vol. 30, No. 3, pp. 913-915, 1991.
C. Zdero et al.; Phytochemistry, vol. 29, No. 10, pp. 3201-3206, 1990.
Miguel P. L. Moraes et al.; Phytochemistry, vol. 27, No. 10, pp. 3205-3208, 1988.
A.M. Giesbrecht et al.; Brazilian J. Med. Biol. Res.; 1987, vol. 20, No. 6, pp. 807-810.
Ngassoum et al, Journal of Essential Oil Research, 1999, vol. 11, No. 3, pp. 283-288.
Fraga, et al, Biochem. Syst. Ecol., 1995, vol. 23, No. 7/8, pp. 835-842.
Ding et al, Phytochemistry, 1991, vol. 30, No. 7, pp. 2413-2415.
Fraga et al, Phytochemistry, 1991, vol. 30, No. 3, pp. 913-915.
Zdero et al, Phytochemistry, 1990, vol. 29, No. 10, pp. 3201-3206.
Moraes et al, Phytochemistry, 1988, vol. 27, No. 10, pp. 3205-3208.
Giesbrecht et al, Braz. J. Med. Biol. Res., 1987, vol. 20, No. 6, pp. 807-810.
St. Pyrek, J. Nat. Prod., 1984, vol. 47, No. 5, pp. 822-827, p. 826.
Mcalees et al, J. Chem. Soc., Perkin Trans. 1, 1975, No. 9, pp. 861-869.
Campbell et al, Can. J. Chem., 1975, vol. 53, No. 1, pp. 20-25.
Carrascal et al, An. Qium, 1977, vol. 73, No. 3, pp. 442-443.
Bell et al, J. Org. Chem, 1966, vol. 31, No. 8, pp. 2536-2542.
Akaike Akinori
Asai Naoki
Asakawa Naoki
Doko Takashi
Mano Nariyasu
Barts Samuel
Eisai R&D Management Co., Ltd.
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