Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Having -c- – wherein x is chalcogen – bonded directly to...
Patent
1987-03-18
1989-02-21
Bond, Robert T.
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Having -c-, wherein x is chalcogen, bonded directly to...
546 19, A61K 31445, C07D49120
Patent
active
048065447
ABSTRACT:
The present invention relates to novel asymmetrical esters derived from 1,4-dihydrophyridine-3,5-dicarboxylic acid, of the formula: ##STR1## in which: R.sub.1 represents a C.sub.1 -C.sub.4 alkyl group, R.sub.2 represents a C.sub.1 -C.sub.4 alkyl group, a benzyl group, a benzoyl group or a phenyl group optionally substituted by one or more C.sub.1 -C.sub.4 alkoxy, C.sub.1 -C.sub.4 alkyl, cyano, nitro, hydroxyl or trifluoromethyl groups or by one or more halogen atoms, and R.sub.3 and R.sub.4, which are identical or different, each represent the hydrogen atom, a nitro group or a chlorine atom, their optical isomers and diastereoisomers and also the corresponding addition salts.
These novel esters are useful in therapy, especially as antihypertensives.
REFERENCES:
patent: 4250312 (1981-02-01), Nakahara et al.
patent: 4250313 (1981-02-01), Nakahara et al.
patent: 4710505 (1987-12-01), Robin et al.
Chemical Abstracts, vol. 82, No. 21, May 26, 1975, p. 627, 28-Heterocycles, No. 140108j.
Bellamy Francois
Pruneau Didier
Robin Jacques
Bond Robert T.
Fournier Innovation et Synergie
LandOfFree
Asymmetrical ester derivatives of 1,4-dihydrophyridine-3,5-dicar does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with Asymmetrical ester derivatives of 1,4-dihydrophyridine-3,5-dicar, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Asymmetrical ester derivatives of 1,4-dihydrophyridine-3,5-dicar will most certainly appreciate the feedback.
Profile ID: LFUS-PAI-O-1522430