Organic compounds -- part of the class 532-570 series – Organic compounds – Fatty compounds having an acid moiety which contains the...
Reexamination Certificate
2005-05-24
2005-05-24
Carr, Deborah D. (Department: 1621)
Organic compounds -- part of the class 532-570 series
Organic compounds
Fatty compounds having an acid moiety which contains the...
C554S063000, C554S209000, C424S450000
Reexamination Certificate
active
06897326
ABSTRACT:
The present invention is a stable, nanometer scale micro-tubular aggregated material of an asymmetric double-headed lipid represented by the general formulain-line-formulae description="In-line Formulae" end="lead"?R—NHCO—(CH2)n—COOH (I)in-line-formulae description="In-line Formulae" end="tail"?(in the formula, R represents an aldopyranose radical from which the terminal reducing hydroxyl group is excluded and n is from six to twenty). The external diameter of the micro-tubular aggregated material is 10-300 nm, and the length is 0.3-10 μm. The micro-tubular aggregated material can be manufactured by dispersing the asymmetric double-headed lipid described above in water at pH of two to eight, next heating to 80-100° C. to dissolve it and then gradually cooling the aqueous solution obtained.
REFERENCES:
Toshimi Shimizu & Mitsutoshi Masuda, Journal of The American Chemical Society, 119, 2812 (1997).
Parrot-Lopez Helene et al., Vectorized transport of drugs; synthesis of a new glycosyl derivative of <SYM98>-Cyclodextrin, Tetrahedron Lett., 1992, vol. 33, No. 2, p. 209-212, esp fig. 1 of p. 210.
Parrot-Lopez Helene et al., New β-cyclodextrin derivatives possessing biologically active saccharide antennae, Supramol. Chemical, 1993, vol. 3, No. 1, p. 37-42, esp. fig. 1 of p. 210.
Masuda Mitsutoshi et al., Multilayer structure of an unsymmetrical monolayer lipid mimbrane with a “head-to-tail” interface, Chemical Communication, Dec., 7, 2001, vol. 23, p. 2442-2443.
Masuda Mitsutoshi
Shimizu Toshimi
Carr Deborah D.
Gary C Cohn PLLC
Japan Science and Technology Corporation
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