Organic compounds -- part of the class 532-570 series – Organic compounds – Amino nitrogen containing
Reexamination Certificate
2004-06-25
2009-12-15
O'Sullivan, Peter G (Department: 1621)
Organic compounds -- part of the class 532-570 series
Organic compounds
Amino nitrogen containing
C564S003000, C564S017000, C564S026000, C564S029000
Reexamination Certificate
active
07632970
ABSTRACT:
The present invention relates to a production method of asymmetric compound (IV) which includes conjugately adding nucleophilic reagent (III) to compound (II) in the presence of asymmetric urea compound (I). The present invention provides a non-metallic asymmetric catalyst capable of realizing a highly stereoselective asymmetric conjugate addition reaction in a high yield, and an advantageous production method of an asymmetric compound by an asymmetric conjugate addition reaction using the asymmetric catalyst.wherein X is an oxygen atom or a sulfur atom; C*, C** and C*** are asymmetric carbons; R1, R2, R4, R5, R8, R9and R10are each a lower alkyl group optionally having substituent(s) and the like, or R4and R5and the like in combination optionally form a homocyclic ring optionally having substituent(s) and the like; R3is an aryl group optionally having substituent(s) and the like; R6and R7are each a hydrogen atom and the like; Nu is —CR16(COR17)(COR18) wherein R16, R17and R18are each a lower alkyl group optionally having substituent(s) and the like, and the like; and EWG is an electron withdrawing group.
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Katakam Sudhakar
O'Sullivan Peter G
Sughrue & Mion, PLLC
Sumitomo Chemical Company Limited
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