Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Heterocyclic carbon compounds containing a hetero ring...
Patent
1993-11-08
1995-07-18
Shah, Mukund J.
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Heterocyclic carbon compounds containing a hetero ring...
514253, 514259, 544110, 544238, 544254, 544286, A61K 31535, A61K 31505, C07D26524, C07D26514
Patent
active
054341523
ABSTRACT:
An asymmetric synthesis of (S)-(-)-6-chloro-4-cyclopropyl-3,4-dihydro-4-[(2-pyridyl)ethynyl]-2(1H)-qu inazolinone comprises the chiral addition of 2-pyridylacetylide to N.sup.1 -protected 6-chloro-4-cyclopropyl-2-quinazolinone followed by removal of the protecting group.
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DeCamp Ann E.
Grabowski Edward J. J.
Huffman Mark A.
Yasuda Nobuyoshi
Grumbling Matthew V.
Merck & Co. , Inc.
Meredith Roy D.
Shah Mukund J.
Tribble Jack L.
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