Asymmetric synthesis of peptides

Details Asymmetric synthesis of peptides Asymmetric synthesis of peptides

2008-03-20

2011-10-25

Ha, Julie (Department: 1654)

Chemistry: natural resins or derivatives; peptides or proteins;

Peptides of 3 to 100 amino acid residues

Cyclic peptides

C530S333000, C530S338000

Reexamination Certificate

active

08044173

ABSTRACT:
A process comprising substitution of an acceptor molecule comprising a group —XC(O)— wherein X is O, S, or NR8, where R8is C1-6alkyl, C6-12aryl or hydrogen, with a nucleophile, wherein the acceptor molecule is cyclised such that said nucleophilic substitution at —XC(O)— occurs without racemisation, is provided. This process has particular application for the production of a peptide by extension from the activated carboxy-terminus of an acyl amino acid residue without epimerisation.

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