Asymmetric synthesis of intermediates for retroviral protease in

Details Asymmetric synthesis of intermediates for retroviral protease in Asymmetric synthesis of intermediates for retroviral protease in

1994-01-14

1995-06-27

Dentz, Bernard

Organic compounds -- part of the class 532-570 series

Organic compounds

Heterocyclic carbon compounds containing a hetero ring...

546147, C07D21700

Patent

active

054281679

ABSTRACT:
The disclosure describes an improved process for producing optically active compounds of Formula II or III, which compounds are useful as intermediates for preparing compounds active as inhibitors of retroviral protease enzymes: ##STR1## wherein R.sub.1, R.sub.50 and Z are described in the specification. The improved process includes either synthesis of diastereomeric iodolactones which are separated prior to conversion to compounds of Formula II or III or synthesis of an epoxide which is converted directly to compounds of Formula II and III.

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